- Conference Paper
Two feedback schemes for controlling nerve cell dynamics governed by Hodgkin-Huxley model were designed and evaluated in computer simulations. By combining a state feedback controller for control of membrane voltage with an optimal controller (model predictive control, MPC), a closed-loop cascaded control of the essential biophysical states causing electrical signal generation in nerve cells was achieved. These states correspond to ion channel opening / closing. The controller exhibited disturbance rejection and permitted control of nerve cell dynamics in noisy conditions. The use of MPC allowed the generation of biophysically plausible control signals by tuning both the MPC cost function and the constraints on the controller output. This new theoretical developments can open new possibilities in the design of electrical rehabilitation systems. Show more
Book titleModelling and Control in Biomedical Systems 2003: a Proceedings Volume from the 5th IFAC Symposium
Journal / seriesIFAC Proceedings Volumes
Pages / Article No.
SubjectApplied neural control; Neural dynamics; Nonlinear control; Optimal control; Medical applications
MoreShow all metadata