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dc.contributor.author
Burden, Andrea
dc.contributor.author
Hausammann, Lucy
dc.contributor.author
Ceschi, Alessandro
dc.contributor.author
Kupferschmidt, Hugo
dc.contributor.author
Weiler, Stefan
dc.date.accessioned
2022-06-22T08:28:10Z
dc.date.available
2022-01-10T16:48:07Z
dc.date.available
2022-01-11T06:30:34Z
dc.date.available
2022-02-11T13:23:25Z
dc.date.available
2022-03-18T06:50:56Z
dc.date.available
2022-05-05T11:32:03Z
dc.date.available
2022-05-11T09:08:59Z
dc.date.available
2022-06-02T11:42:28Z
dc.date.available
2022-06-22T08:28:10Z
dc.date.issued
2022-06
dc.identifier.other
10.1016/j.jgar.2021.11.010
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/524365
dc.identifier.doi
10.3929/ethz-b-000524365
dc.description.abstract
Introduction: In this study we examined the toxicities, including poisoning and overdoses, with polyene, azole, flucytosine and echinocandin antifungals reported to the National Poison Center. Methods: An observational cross-sectional study on antifungals was performed based on reports between 1995 and 2016 to Tox Info Suisse. Patient demographic and clinical characteristics were summarized among all reported calls, stratified by age group. In secondary analyses, we evaluated cases with clinical follow-up information. Results: In total, 149 cases were reported to the National Poison Centre within the study period of which 49 (32.9%) were male and 91 (61.1%) were female. 95 (63.8%) were adults and 54 (36.2%) were children (age ≤ 16). The most frequently reported drug class were the azoles (n=136, 91.3%). In 31 cases (21%) reported by the treating physicians, further clinical follow-up information was available. Nearly half of these patients were asymptomatic (n=15, 48%). Among those with symptoms, in 11 (33%) patients, the symptoms of toxicity were categorized with a strong causality to the respective antifungal. Clinical findings caused by the triazoles were effects in the gastrointestinal tract, hallucinations and predilirium state. The clinical findings caused by the polyenes were mostly minor symptoms with infusion-related effects or hypokalemia. In 6 (54.6%) out of 11 cases the severity was categorized as minor and for 5 (45.5%) as moderate, respectively. Conclusion: Despite high administered doses, no severe or fatal cases occurred within the study period. Although various toxicities can occur with antifungal administration and overdoses, they showed a favorable safety profile.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
pharmacovigilance
en_US
dc.title
Observational cross-sectional case study of toxicities of antifungal drugs
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2021-12-08
ethz.journal.title
Journal of Global Antimicrobial Resistance
ethz.journal.volume
29
en_US
ethz.pages.start
520
en_US
ethz.pages.end
526
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
en_US
ethz.date.deposited
2022-01-10T16:48:13Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-06-22T08:28:16Z
ethz.rosetta.lastUpdated
2022-06-22T08:28:16Z
ethz.rosetta.versionExported
true
ethz.COinS
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