Yin Yang 1 sustains biosynthetic demands duringbrain development in a stage-specific manner

Open access
Date
2019-05-16Type
- Journal Article
Citations
Cited 13 times in
Web of Science
Cited 17 times in
Scopus
ETH Bibliography
yes
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Abstract
The transcription factor Yin Yang 1 (YY1) plays an important role in human disease. It is often overexpressed in cancers and mutations can lead to a congenital haploinsufficiency syndrome characterized by craniofacial dysmorphisms and neurological dysfunctions, consistent with a role in brain development. Here, we show that Yy1 controls murine cerebral cortex development in a stage-dependent manner. By regulating a wide range of metabolic pathways and protein translation, Yy1 maintains proliferation and survival of neural progenitor cells (NPCs) at early stages of brain development. Despite its constitutive expression, however, the dependence on Yy1 declines over the course of corticogenesis. This is associated with decreasing importance of processes controlled by Yy1 during development, as reflected by diminished protein synthesis rates at later developmental stages. Thus, our study unravels a novel role for Yy1 as a stage-dependent regulator of brain development and shows that biosynthetic demands of NPCs dynamically change throughout development. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000344712Publication status
publishedExternal links
Journal / series
Nature CommunicationsVolume
Pages / Article No.
Publisher
Nature Publishing GroupOrganisational unit
08839 - Zamboni, Nicola (Tit.-Prof.)
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Citations
Cited 13 times in
Web of Science
Cited 17 times in
Scopus
ETH Bibliography
yes
Altmetrics