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dc.contributor.author
Zurkirchen, Luis
dc.contributor.author
Varum, Sandra
dc.contributor.author
Giger, Sonja
dc.contributor.author
Klug, Annika
dc.contributor.author
Häusel, Jessica
dc.contributor.author
Bossart, Raphaël
dc.contributor.author
Zemke, Martina
dc.contributor.author
Cantù, Claudio
dc.contributor.author
Kalender Atak, Zeynep
dc.contributor.author
Zamboni, Nicola
dc.contributor.author
Basler, Konrad
dc.contributor.author
Sommer, Lukas
dc.date.accessioned
2022-01-19T13:18:32Z
dc.date.available
2022-01-19T13:18:32Z
dc.date.issued
2019-05-16
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-019-09823-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/526906
dc.identifier.doi
10.3929/ethz-b-000344712
dc.description.abstract
The transcription factor Yin Yang 1 (YY1) plays an important role in human disease. It is often overexpressed in cancers and mutations can lead to a congenital haploinsufficiency syndrome characterized by craniofacial dysmorphisms and neurological dysfunctions, consistent with a role in brain development. Here, we show that Yy1 controls murine cerebral cortex development in a stage-dependent manner. By regulating a wide range of metabolic pathways and protein translation, Yy1 maintains proliferation and survival of neural progenitor cells (NPCs) at early stages of brain development. Despite its constitutive expression, however, the dependence on Yy1 declines over the course of corticogenesis. This is associated with decreasing importance of processes controlled by Yy1 during development, as reflected by diminished protein synthesis rates at later developmental stages. Thus, our study unravels a novel role for Yy1 as a stage-dependent regulator of brain development and shows that biosynthetic demands of NPCs dynamically change throughout development.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Yin Yang 1 sustains biosynthetic demands duringbrain development in a stage-specific manner
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Nature Communications
ethz.journal.volume
10
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
2192
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::08839 - Zamboni, Nicola (Tit.-Prof.)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::08839 - Zamboni, Nicola (Tit.-Prof.)
ethz.date.deposited
2019-05-29T13:44:32Z
ethz.source
WOS
ethz.source
BATCH
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-01-19T13:18:40Z
ethz.rosetta.lastUpdated
2022-03-29T17:41:36Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/344712
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/525522
ethz.COinS
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