Show simple item record

dc.contributor.author
van Steenwyk, Gretchen
dc.contributor.author
Gapp, Katharina
dc.contributor.author
Jawaid, Ali
dc.contributor.author
Germain, Pierre-Luc
dc.contributor.author
Manuella, Francesca
dc.contributor.author
Tanwar, Deepak K.
dc.contributor.author
Zamboni, Nicola
dc.contributor.author
Gaur, Niharika
dc.contributor.author
Efimova, Anastasiia
dc.contributor.author
Thumfart, Kristina M.
dc.contributor.author
Miska, Eric A.
dc.contributor.author
Mansuy, Isabelle
dc.date.accessioned
2022-01-19T13:23:18Z
dc.date.available
2022-01-19T13:23:18Z
dc.date.issued
2020-12-01
dc.identifier.issn
0261-4189
dc.identifier.issn
1460-2075
dc.identifier.other
10.15252/embj.2020104579
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/526910
dc.identifier.doi
10.3929/ethz-b-000448267
dc.description.abstract
Environmental factors can change phenotypes in exposed individuals and offspring and involve the germline, likely via biological signals in the periphery that communicate with germ cells. Here, using a mouse model of paternal exposure to traumatic stress, we identify circulating factors involving peroxisome proliferator‐activated receptor (PPAR) pathways in the effects of exposure to the germline. We show that exposure alters metabolic functions and pathways, particularly lipid‐derived metabolites, in exposed fathers and their offspring. We collected data in a human cohort exposed to childhood trauma and observed similar metabolic alterations in circulation, suggesting conserved effects. Chronic injection of serum from trauma‐exposed males into controls recapitulates metabolic phenotypes in the offspring. We identify lipid‐activated nuclear receptors PPARs as potential mediators of the effects from father to offspring. Pharmacological PPAR activation in vivo reproduces metabolic dysfunctions in the offspring and grand‐offspring of injected males and affects the sperm transcriptome in fathers and sons. In germ‐like cells in vitro, both serum and PPAR agonist induce PPAR activation. Together, these results highlight the role of circulating factors as potential communication vectors between the periphery and the germline.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
blood serum
en_US
dc.subject
paternal experiences
en_US
dc.subject
PPAR
en_US
dc.subject
sperm
en_US
dc.subject
transmission
en_US
dc.title
Involvement of circulating factors in the transmission of paternal experiences through the germline
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2020-10-09
ethz.journal.title
The EMBO Journal
ethz.journal.volume
39
en_US
ethz.journal.issue
23
en_US
ethz.journal.abbreviated
EMBO J
ethz.pages.start
e104579
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::03518 - Mansuy, Isabelle / Mansuy, Isabelle
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::08839 - Zamboni, Nicola (Tit.-Prof.)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::03518 - Mansuy, Isabelle / Mansuy, Isabelle
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::08839 - Zamboni, Nicola (Tit.-Prof.)
ethz.date.deposited
2020-10-28T03:53:23Z
ethz.source
WOS
ethz.source
BATCH
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-01-19T13:23:26Z
ethz.rosetta.lastUpdated
2022-03-29T17:41:38Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/448267
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/463998
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/466716
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/525512
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Involvement%20of%20circulating%20factors%20in%20the%20transmission%20of%20paternal%20experiences%20through%20the%20germline&rft.jtitle=The%20EMBO%20Journal&rft.date=2020-12-01&rft.volume=39&rft.issue=23&rft.spage=e104579&rft.issn=0261-4189&1460-2075&rft.au=van%20Steenwyk,%20Gretchen&Gapp,%20Katharina&Jawaid,%20Ali&Germain,%20Pierre-Luc&Manuella,%20Francesca&rft.genre=article&rft_id=info:doi/10.15252/embj.2020104579&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record