Longevity interventions temporally scale healthspan in Caenorhabditis elegans
- Journal Article
Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity, i.e., “sickspan,” is highly debated even in isogenic Caenorhabditis elegans. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in aging C. elegans. Together with different biomarkers for healthspan, we found a stochastic onset of morbidity, starting with a decline in dynamic muscle power and structural integrity, culminating in frailty. Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan. Given the conservation of these longevity interventions, this raises the question of whether the healthspan of mammalian longevity interventions is also temporally scaled. Show more
Journal / seriesiScience
Pages / Article No.
SubjectBiological sciences; Physiology; Biophysics
Organisational unit03307 - Dual, Jürg (emeritus) / Dual, Jürg (emeritus)
09598 - Ewald, Collin Y. / Ewald, Collin Y.
163898 - The role of extracellular matrix enhancement in promoting healthy aging (SNF)
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Is new version of: https://doi.org/10.3929/ethz-b-000525654
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