Longevity interventions temporally scale healthspan in Caenorhabditis elegans
Open access
Date
2022-03-18Type
- Journal Article
Abstract
Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity, i.e., “sickspan,” is highly debated even in isogenic Caenorhabditis elegans. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in aging C. elegans. Together with different biomarkers for healthspan, we found a stochastic onset of morbidity, starting with a decline in dynamic muscle power and structural integrity, culminating in frailty. Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan. Given the conservation of these longevity interventions, this raises the question of whether the healthspan of mammalian longevity interventions is also temporally scaled. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000537535Publication status
publishedExternal links
Journal / series
iScienceVolume
Pages / Article No.
Publisher
Cell PressSubject
Biological sciences; Physiology; BiophysicsOrganisational unit
03307 - Dual, Jürg (emeritus) / Dual, Jürg (emeritus)
09598 - Ewald, Collin Y. (ehemalig) / Ewald, Collin Y. (former)
Funding
163898 - The role of extracellular matrix enhancement in promoting healthy aging (SNF)
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Is new version of: https://doi.org/10.3929/ethz-b-000525654
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