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dc.contributor.author
Diebold, Martin
dc.contributor.author
Galli, Edoardo
dc.contributor.author
Kopf, Andreas
dc.contributor.author
Sanderson, Nicholas
dc.contributor.author
Callegari, Ilaria
dc.contributor.author
Ingelfinger, Florian
dc.contributor.author
Gonzalo Núñez, Nicolás
dc.contributor.author
Benkert, Pascal
dc.contributor.author
Kappos, Ludwig
dc.contributor.author
Kuhle, Jens
dc.contributor.author
Becher, Burkhard
dc.contributor.author
Claassen, Manfred
dc.contributor.author
Derfuss, Tobias
dc.date.accessioned
2022-06-20T12:06:37Z
dc.date.available
2022-03-22T04:50:24Z
dc.date.available
2022-06-20T12:06:37Z
dc.date.issued
2022-05
dc.identifier.issn
0364-5134
dc.identifier.issn
1531-8249
dc.identifier.other
10.1002/ana.26328
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/538280
dc.identifier.doi
10.3929/ethz-b-000538280
dc.description.abstract
Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population negatively associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2022-02-16
ethz.journal.title
Annals of Neurology
ethz.journal.volume
91
en_US
ethz.journal.issue
5
en_US
ethz.journal.abbreviated
Ann Neurol
ethz.pages.start
676
en_US
ethz.pages.end
681
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-03-22T04:51:02Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-06-20T12:06:45Z
ethz.rosetta.lastUpdated
2023-02-07T03:37:46Z
ethz.rosetta.versionExported
true
ethz.COinS
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