Conserved exchange of paralog proteins during neuronal differentiation
dc.contributor.author
Di Fraia, Domenico
dc.contributor.author
Anitei, Mihaela
dc.contributor.author
Mackmull, Marie-Therese
dc.contributor.author
Parca, Luca
dc.contributor.author
Behrendt, Laura
dc.contributor.author
Andrés-Pons, Amparo
dc.contributor.author
Gilmour, Darren
dc.contributor.author
Helmer-Citterich, Manuela
dc.contributor.author
Kaether, Christoph
dc.contributor.author
Beck, Martin
dc.contributor.author
Ori, Alessandro
dc.date.accessioned
2022-06-20T16:46:19Z
dc.date.available
2022-03-23T04:21:44Z
dc.date.available
2022-06-20T16:46:19Z
dc.date.issued
2022-06
dc.identifier.issn
2575-1077
dc.identifier.other
10.26508/lsa.202201397
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/538594
dc.identifier.doi
10.3929/ethz-b-000538594
dc.description.abstract
Gene duplication enables the emergence of new functions by lowering the evolutionary pressure that is posed on the ancestral genes. Previous studies have highlighted the role of specific paralog genes during cell differentiation, for example, in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to other biological functions and whether the regulation of paralog genes is conserved across species. Here, we analyze the expression of paralogs across human tissues, during development and neuronal differentiation in fish, rodents and humans. Whereas ∼80% of paralog genes are co-regulated, a subset of paralogs shows divergent expression profiles, contributing to variability of protein complexes. We identify 78 substitutions of paralog pairs that occur during neuronal differentiation and are conserved across species. Among these, we highlight a substitution between the paralogs SEC23A and SEC23B members of the COPII complex. Altering the ratio between these two genes via RNAi-mediated knockdown is sufficient to influence neuron differentiation. We propose that remodeling of the vesicular transport system via paralog substitutions is an evolutionary conserved mechanism enabling neuronal differentiation.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
EMBO Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Conserved exchange of paralog proteins during neuronal differentiation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2022-03-10
ethz.journal.title
Life Science Alliance
ethz.journal.volume
5
en_US
ethz.journal.issue
6
en_US
ethz.pages.start
e202201397
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Heidelberg
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-03-23T04:21:48Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-06-20T16:46:25Z
ethz.rosetta.lastUpdated
2023-02-07T03:38:25Z
ethz.rosetta.versionExported
true
ethz.COinS
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Journal Article [133598]