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dc.contributor.author
Kummer, Thomas
dc.contributor.author
Rossi, Simone
dc.contributor.author
Vandenberghe, Stijn
dc.contributor.author
Demertzis, Stefanos
dc.contributor.author
Jenny, Patrick
dc.date.accessioned
2022-06-15T07:22:23Z
dc.date.available
2022-03-29T03:25:14Z
dc.date.available
2022-06-15T07:22:23Z
dc.date.issued
2022
dc.identifier.issn
1869-408X
dc.identifier.issn
1869-4098
dc.identifier.other
10.1007/s13239-022-00610-w
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/539655
dc.description.abstract
Purpose External cardiac assist devices are based on a promising and simple concept for treating heart failure, but they are surprisingly difficult to design. Thus, a structured approach combining experiments with computer-based optimization is essential. The latter provides the motivation for the work presented in this paper. Methods We present a computational modeling framework for realistic representation of the heart's tissue structure, electrophysiology and actuation. The passive heart tissue is described by a nonlinear anisotropic material law, considering fiber and sheetlet directions. For muscle contraction, an orthotropic active-strain model is employed, initiated by a periodically propagating electrical potential. The model allows for boundary conditions at the epicardium accounting for external assist devices, and it is coupled to a circulation network providing appropriate pressure boundary conditions inside the ventricles. Results Simulated results from an unsupported healthy and a pathological heart model are presented and reproduce accurate deformations compared to phenomenological measurements. Moreover, cardiac output and ventricular pressure signals are in good agreement too. By investigating the impact of applying an exemplary external actuation to the pathological heart model, it shows that cardiac patches can restore a healthy blood flow. Conclusion We demonstrate that the devised computational modeling framework is capable of predicting characteristic trends (e.g. apex shortening, wall thickening and apex twisting) of a healthy heart, and that it can be used to study pathological hearts and external activation thereof.
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.subject
External ventricular assist device
en_US
dc.subject
Direct cardiac contractor
en_US
dc.subject
Medical device development
en_US
dc.subject
Three dimensional heart modeling
en_US
dc.subject
Active strain actuation
en_US
dc.subject
Lumped parameter circulation
en_US
dc.subject
Hydraulic network model
en_US
dc.title
Embedded Computational Heart Model for External Ventricular Assist Device Investigations
en_US
dc.type
Journal Article
dc.date.published
2022-03-15
ethz.journal.title
Cardiovascular Engineering and Technology
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02628 - Institut für Fluiddynamik / Institute of Fluid Dynamics::03644 - Jenny, Patrick / Jenny, Patrick
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02628 - Institut für Fluiddynamik / Institute of Fluid Dynamics::03644 - Jenny, Patrick / Jenny, Patrick
ethz.date.deposited
2022-03-29T03:25:50Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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