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dc.contributor.author
Hösli, Ladina
dc.contributor.author
Zuend, Marc
dc.contributor.author
Bredell, Gustav
dc.contributor.author
Zanker, Henri S.
dc.contributor.author
Porto de Oliveira, Carlos Eduardo
dc.contributor.author
Saab, Aiman S.
dc.contributor.author
Weber, Bruno
dc.date.accessioned
2022-04-25T14:12:51Z
dc.date.available
2022-04-11T03:17:36Z
dc.date.available
2022-04-25T14:12:51Z
dc.date.issued
2022-04-05
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2022.110599
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/541839
dc.identifier.doi
10.3929/ethz-b-000541839
dc.description.abstract
Astrocytes establish extensive networks via gap junctions that allow each astrocyte to connect indirectly to the vasculature. However, the proportion of astrocytes directly associated with blood vessels is unknown. Here, we quantify structural contacts of cortical astrocytes with the vasculature in vivo. We show that all cortical astrocytes are connected to at least one blood vessel. Moreover, astrocytes contact more vessels in deeper cortical layers where vessel density is known to be higher. Further examination of different brain regions reveals that only the hippocampus, which has the lowest vessel density of all investigated brain regions, harbors single astrocytes with no apparent vascular connection. In summary, we show that almost all gray matter astrocytes have direct contact to the vasculature. In addition to the glial network, a direct vascular access may represent a complementary pathway for metabolite uptake and distribution.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Direct vascular contact is a hallmark of cerebral astrocytes
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2022-04-05
ethz.journal.title
Cell Reports
ethz.journal.volume
39
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
110599
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Maryland Heights, MO
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-04-11T03:17:41Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-04-25T14:13:00Z
ethz.rosetta.lastUpdated
2023-02-07T00:56:53Z
ethz.rosetta.versionExported
true
ethz.COinS
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