Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density

Open access
Datum
2022-03-14Typ
- Journal Article
Abstract
Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that 5 h of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from a single episode of sleep deprivation. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000542514Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Frontiers in Synaptic NeuroscienceBand
Seiten / Artikelnummer
Verlag
Frontiers MediaThema
sleep deprivation; plasticity; spines; dendrite; hippocampus