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dc.contributor.author
Hurrell, Richard F.
dc.contributor.author
Trinidad, Trinidad P.
dc.contributor.author
Mallillin, Aida C.
dc.contributor.author
Sagum, Rosario S.
dc.contributor.author
Tajeri Foman, Jasmin
dc.contributor.author
Li, Qiaoji
dc.contributor.author
Zeder, Christophe
dc.contributor.author
Kastenmayer, Peter
dc.contributor.author
Rytz, Andreas
dc.contributor.author
Sabatier, Magalie
dc.contributor.author
Egli, Ines
dc.date.accessioned
2022-04-25T16:22:03Z
dc.date.available
2022-04-23T03:53:32Z
dc.date.available
2022-04-25T16:22:03Z
dc.date.issued
2022-04-02
dc.identifier.issn
2072-6643
dc.identifier.other
10.3390/nu14081640
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/543434
dc.identifier.doi
10.3929/ethz-b-000543434
dc.description.abstract
Ferrous ammonium phosphate (FAP) is an iron salt that has been developed for the fortification of food matrices sensitive to color and flavor changes. The objective of the study was to measure iron absorption from FAP in young children and compare it to a previous evaluation of FAP in young women. A double-blind randomized crossover study with two parallel arms was used to evaluate the iron absorption from FAP added to reconstituted milk powder in comparison to that from ferrous sulfate (FeSO4 ) and ferric pyrophosphate (FePP). Iron absorption was measured in 39 children aged 3-to 6-years-old using erythrocyte incorporation of stable Fe isotopes (57Fe,58Fe). The geometric mean iron absorption in iron replete children from FAP, FeSO4 and FePP from milk was 8.3%, 7.6% and 2.1%, respectively. Iron absorption from FAP and FeSO4 fortified milk was not significantly different (p = 0.199); however, it was significantly higher than from FePP fortified milk (p < 0.001). Iron bioavailability from FAP and FePP relative to FeSO4 (relative bioavailability (RBV)) was 110% and 33%, respectively. The RBV of FAP (110%) in iron replete children was higher than previously reported RBV (71%) in mainly iron deficient women. The difference in iron status between the children and women in the respective studies may explain the different RBV values and is discussed.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
ferrous sulfate
en_US
dc.subject
ferrous ammonium phosphate
en_US
dc.subject
ferric pyrophosphate
en_US
dc.subject
stable isotope
en_US
dc.subject
absorption
en_US
dc.subject
milk
en_US
dc.subject
children
en_US
dc.title
Iron Bioavailability from Ferrous Ammonium Phosphate, Ferrous Sulfate, and Ferric Pyrophosphate in an Instant Milk Drink—A Stable Isotope Study in Children
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Nutrients
ethz.journal.volume
14
en_US
ethz.journal.issue
8
en_US
ethz.pages.start
1640
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-04-23T03:53:42Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-04-25T16:22:18Z
ethz.rosetta.lastUpdated
2023-02-07T00:57:02Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.atitle=Iron%20Bioavailability%20from%20Ferrous%20Ammonium%20Phosphate,%20Ferrous%20Sulfate,%20and%20Ferric%20Pyrophosphate%20in%20an%20Instant%20Milk%20Drink%E2%80%94A%20Stable&amp;rft.jtitle=Nutrients&amp;rft.date=2022-04-02&amp;rft.volume=14&amp;rft.issue=8&amp;rft.spage=1640&amp;rft.issn=2072-6643&amp;rft.au=Hurrell,%20Richard%20F.&amp;Trinidad,%20Trinidad%20P.&amp;Mallillin,%20Aida%20C.&amp;Sagum,%20Rosario%20S.&amp;Tajeri%20Foman,%20Jasmin&amp;rft.genre=article&amp;rft_id=info:doi/10.3390/nu14081640&amp;
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