A Natural Low Phytic Acid Finger Millet Accession Significantly Improves Iron Bioavailability in Indian Women
dc.contributor.author
Rajashekar Reddy, Bellam H.
dc.contributor.author
Thankachan, Prashanth
dc.contributor.author
Hatakayama, Masoami
dc.contributor.author
Hiremath, Netravati
dc.contributor.author
Moretti, Diego
dc.contributor.author
Nanjareddy, Yellodu A.
dc.contributor.author
Thumilan, Mathi B.
dc.contributor.author
Ravikumar, Ramapura L.
dc.contributor.author
Phadnis, Shamprasad
dc.contributor.author
Bose, Beena
dc.contributor.author
Poveda, Lucy
dc.contributor.author
Kalaiah, Geetha
dc.contributor.author
Zimmermann, Michael B.
dc.contributor.author
Shimizu, Kentaro K.
dc.contributor.author
Schlapbach, Ralph
dc.contributor.author
Kurpad, Anura V.
dc.contributor.author
Sreeman, Sheshshayee M.
dc.date.accessioned
2022-04-25T08:00:01Z
dc.date.available
2022-04-25T02:57:51Z
dc.date.available
2022-04-25T08:00:01Z
dc.date.issued
2022-03-24
dc.identifier.issn
2296-861X
dc.identifier.other
10.3389/fnut.2021.791392
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/543560
dc.identifier.doi
10.3929/ethz-b-000543560
dc.description.abstract
Iron deficiency and anemia are common in low- and middle-income countries. This is due to a poor dietary iron density and low iron absorption resulting from the high inhibitory phytic acid content in cereal and millet-based diets. Here, we report that a naturally occurring low phytic acid finger millet accession (571 mg 100 g(-1)), stable across three growing seasons with normal iron content (3.6 mg 100 g(-1)), increases iron absorption by 3-folds in normal Indian women. The accessions differing in grain phytic acid content, GE 2358 (low), and GE1004 (high) were selected from a core collection of 623 accessions. Whole genome re-sequencing of the accessions revealed significant single nucleotide variations segregating them into distinct clades. A non-synonymous mutation in the EcABCC phytic acid transporter gene between high and low accessions could affect gene function and result in phytic acid differences. The highly sensitive dual stable-isotope erythrocyte incorporation method was adopted to assess the fractional iron absorption. The low phytic acid accession resulted in a significantly higher iron absorption compared with the high phytic acid accession (3.7 vs. 1.3%, p < 0.05). The low phytic acid accession could be effective in preventing iron deficiency in regions where finger millet is habitually eaten. With its low water requirement, finger millet leaves low environmental footprints and hence would be an excellent sustainable strategy to mitigate iron deficiency.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Media
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
finger millet
en_US
dc.subject
grain phytic acid
en_US
dc.subject
iron deficiency anemia (IDA)
en_US
dc.subject
bioavailability
en_US
dc.subject
stable isotope
en_US
dc.title
A Natural Low Phytic Acid Finger Millet Accession Significantly Improves Iron Bioavailability in Indian Women
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Frontiers in Nutrition
ethz.journal.volume
8
en_US
ethz.journal.abbreviated
Front. Nutr.
ethz.pages.start
791392
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Lausanne
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce (emeritus) / Zimmermann, Michael Bruce (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce (emeritus) / Zimmermann, Michael Bruce (emeritus)
ethz.date.deposited
2022-04-25T02:58:52Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-04-25T08:00:19Z
ethz.rosetta.lastUpdated
2024-02-02T16:44:46Z
ethz.rosetta.versionExported
true
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