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dc.contributor.author
Dultz, Elisa
dc.contributor.author
Wojtynek, Matthias
dc.contributor.author
Medalia, Ohad
dc.contributor.author
Onischenko, Evgeny
dc.date.accessioned
2022-05-24T06:58:49Z
dc.date.available
2022-05-04T03:13:17Z
dc.date.available
2022-05-24T06:58:49Z
dc.date.issued
2022-05-01
dc.identifier.issn
2073-4409
dc.identifier.other
10.3390/cells11091456
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/544953
dc.identifier.doi
10.3929/ethz-b-000544953
dc.description.abstract
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells. Thanks to advances in structural analysis approaches, the construction principles and architecture of the NPC have recently been revealed at submolecular resolution. Although the overall structure and inventory of nucleoporins are conserved, NPCs exhibit significant compositional and functional plasticity even within single cells and surprising variability in their assembly pathways. Once assembled, NPCs remain seemingly unexchangeable in post-mitotic cells. There are a number of as yet unresolved questions about how the versatility of NPC assembly and composition is established, how cells monitor the functional state of NPCs or how they could be renewed. Here, we review current progress in our understanding of the key aspects of NPC architecture and lifecycle.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
nuclear pore complex
en_US
dc.subject
nucleoporin
en_US
dc.subject
NPC
en_US
dc.subject
membrane fusion
en_US
dc.subject
Ran
en_US
dc.subject
lipids
en_US
dc.subject
assembly factor
en_US
dc.subject
amphipathic helix
en_US
dc.subject
nuclear transport receptor
en_US
dc.subject
FG repeats
en_US
dc.subject
Brl1
en_US
dc.subject
autophagy
en_US
dc.subject
ageing
en_US
dc.subject
aggregation
en_US
dc.subject
neurodegneration
en_US
dc.title
The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Cells
ethz.journal.volume
11
en_US
ethz.journal.issue
9
en_US
ethz.pages.start
1456
en_US
ethz.size
28 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-05-04T03:13:23Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-05-24T06:58:58Z
ethz.rosetta.lastUpdated
2022-05-24T06:58:58Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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