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dc.contributor.author
Lohmann, Sophie C.
dc.contributor.author
Tripathy, Abinash
dc.contributor.author
Milionis, Athanasios
dc.contributor.author
Keller, Anja
dc.contributor.author
Poulikakos, Dimos
dc.date.accessioned
2022-05-09T15:39:35Z
dc.date.available
2022-05-08T03:39:39Z
dc.date.available
2022-05-09T15:39:35Z
dc.date.issued
2022-04-18
dc.identifier.issn
2576-6422
dc.identifier.other
10.1021/acsabm.1c01318
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/545758
dc.description.abstract
Driven by the growing threat of antimicrobial resistance, the design of intrinsically bactericidal surfaces has been gaining significant attention. Proposed surface topography designs are often inspired by naturally occurring nanopatterns on insect wings that mechanically damage bacteria via membrane deformation. The stability of and the absence of chemicals in such surfaces support their facile and sustainable employment in avoiding surface-born pathogen transmission. Recently, the deflection of controllably nanofabricated pillar arrays has been shown to strongly affect bactericidal activity, with the limits of mechanical effectiveness of such structures remaining largely unexplored. Here, we examine the limits of softer, commonly used polymeric materials and investigate the interplay between pillar nanostructure sizing and flexibility for effective antibacterial functionality. A facile, scalable, UV nanoimprint lithography method was used to fabricate nanopillar array topographies of variable sizes and flexibilities. It was found that bacterial death on nanopillars in the range of diameters ≤100 nm and Young's moduli ≥1.3 GPa is increased by 3.5- to 5.6-fold, while thicker or softer pillars did not reduce bacterial viability. To further support our findings, we performed a finite element analysis of pillar deformation. It revealed that differences in the amount of stress exerted on bacterial membranes, generated from the stored elastic energy in flexible pillars, contribute to the observed bactericidal performance.
en_US
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
dc.subject
bactericidal surfaces
en_US
dc.subject
polymers
en_US
dc.subject
soft surfaces
en_US
dc.subject
Nanoimprint lithography
en_US
dc.subject
bactericidal mechanism
en_US
dc.subject
elastic energy
en_US
dc.subject
Young’s modulus
en_US
dc.title
Effect of Flexibility and Size of Nanofabricated Topographies on the Mechanobactericidal Efficacy of Polymeric Surfaces
en_US
dc.type
Journal Article
dc.date.published
2022-02-18
ethz.journal.title
ACS Applied Bio Materials
ethz.journal.volume
5
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
ACS Appl. Bio Mater.
ethz.pages.start
1564
en_US
ethz.pages.end
1575
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
ethz.publication.status
published
en_US
ethz.date.deposited
2022-05-08T03:39:52Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2022-05-09T15:39:42Z
ethz.rosetta.lastUpdated
2024-02-02T16:51:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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