Investigation of the influence of viscoelasticity on oncotripsy
dc.contributor.author
Heyden, Stefanie
dc.contributor.author
Ortiz, Michael
dc.date.accessioned
2022-05-25T09:20:31Z
dc.date.available
2022-05-24T13:35:19Z
dc.date.available
2022-05-25T09:20:31Z
dc.date.issued
2017-02-01
dc.identifier.issn
0045-7825
dc.identifier.issn
1879-2138
dc.identifier.other
10.1016/j.cma.2016.08.026
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/548877
dc.description.abstract
Oncotripsy has recently been proposed as a means of selectively targeting cancer cells via resonant harmonic excitation (Heyden and Ortiz, 2016). The method makes use of aberrations in material properties of cancerous cells which allow to induce local resonance up to membrane lysis in cancerous cells while leaving healthy cells intact. Here, we explore the influence of viscoelasticity on the oncotripsy effect. Based on Rayleigh damping, we derive viscoelastic target frequencies and simulate the fully nonlinear transient response of healthy and cancerous cells at resonance. Results confirm the viability of oncotripsy with viscoelastic material behavior of cell constituents accounted for.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Oncotripsy
en_US
dc.subject
Viscoelasticity
en_US
dc.subject
Local resonance
en_US
dc.subject
Cell lysis
en_US
dc.title
Investigation of the influence of viscoelasticity on oncotripsy
en_US
dc.type
Journal Article
dc.type
Journal Article
ethz.journal.title
Computer Methods in Applied Mechanics and Engineering
ethz.journal.volume
314
en_US
ethz.journal.abbreviated
Comput. Methods Appl. Mech. Eng.
ethz.pages.start
314
en_US
ethz.pages.end
322
en_US
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02160 - Dep. Materialwissenschaft / Dep. of Materials::09573 - Dufresne, Eric (ehemalig) / Dufresne, Eric (former)
en_US
ethz.identifier.orcidWorkCode
46942637
ethz.date.deposited
2022-05-24T13:35:26Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2022-05-25T09:20:40Z
ethz.rosetta.lastUpdated
2022-05-25T09:20:40Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Investigation%20of%20the%20influence%20of%20viscoelasticity%20on%20oncotripsy&rft.jtitle=Computer%20Methods%20in%20Applied%20Mechanics%20and%20Engineering&rft.date=2017-02-01&rft.volume=314&rft.spage=314&rft.epage=322&rft.issn=0045-7825&1879-2138&rft.au=Heyden,%20Stefanie&Ortiz,%20Michael&rft.genre=article&article&rft_id=info:doi/10.1016/j.cma.2016.08.026&
Files in this item
| Files | Size | Format | Open in viewer |
|---|---|---|---|
|
There are no files associated with this item. |
|||
Publication type
-
Journal Article [125578]