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dc.contributor.author
Esposito, Davide
dc.contributor.author
Hurevich, Mattan
dc.contributor.author
Castagner, Bastien
dc.contributor.author
Wang, Cheng-Chung
dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2019-09-10T08:15:49Z
dc.date.available
2017-06-10T08:54:29Z
dc.date.available
2019-09-10T08:15:49Z
dc.date.issued
2012-09-21
dc.identifier.issn
1860-5397
dc.identifier.other
10.3762/bjoc.8.183
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/55542
dc.identifier.doi
10.3929/ethz-b-000055542
dc.description.abstract
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Beilstein-Institut zur Förderung der Chemischen Wissenschaften
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/
dc.subject
Automated synthesis
en_US
dc.subject
Disaccharide building blocks
en_US
dc.subject
Solid-phase
en_US
dc.subject
Synthesis
en_US
dc.subject
Sialic acid
en_US
dc.subject
Sialosides
en_US
dc.title
Automated synthesis of sialylated oligosaccharides
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 2.0 Generic
ethz.journal.title
Beilstein Journal of Organic Chemistry
ethz.journal.volume
8
en_US
ethz.journal.abbreviated
Beilstein j. org. chem.
ethz.pages.start
1601
en_US
ethz.pages.end
1609
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005067134
ethz.publication.place
Frankfurt am Main
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
ethz.date.deposited
2017-06-10T08:55:25Z
ethz.source
ECIT
ethz.identifier.importid
imp59364fc01796123402
ethz.ecitpid
pub:89523
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T19:15:42Z
ethz.rosetta.lastUpdated
2019-09-10T08:15:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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