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dc.contributor.author
Ring, Alexander
dc.contributor.author
Spataro, Maria
dc.contributor.author
Wicki, Andreas
dc.contributor.author
Aceto, Nicola
dc.date.accessioned
2022-07-22T13:38:42Z
dc.date.available
2022-07-21T03:30:11Z
dc.date.available
2022-07-22T13:38:42Z
dc.date.issued
2022-06-28
dc.identifier.issn
2296-634X
dc.identifier.other
10.3389/fcell.2022.929893
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/559198
dc.identifier.doi
10.3929/ethz-b-000559198
dc.description.abstract
Progress in detection and treatment have drastically improved survival for early breast cancer patients. However, distant recurrence causes high mortality and is typically considered incurable. Cancer dissemination occurs via circulating tumor cells (CTCs) and up to 75% of breast cancer patients could harbor micrometastatses at time of diagnosis, while metastatic recurrence often occurs years to decades after treatment. During clinical latency, disseminated tumor cells (DTCs) can enter a state of cell cycle arrest or dormancy at distant sites, and are likely shielded from immune detection and treatment. While this is a challenge, it can also be seen as an outstanding opportunity to target dormant DTCs on time, before their transformation into lethal macrometastatic lesions. Here, we review and discuss progress made in our understanding of DTC and dormancy biology in breast cancer. Strides in our mechanistic insights of these features has led to the identification of possible targeting strategies, yet, their integration into clinical trial design is still uncertain. Incorporating minimally invasive liquid biopsies and rationally designed adjuvant therapies, targeting both proliferating and dormant tumor cells, may help to address current challenges and improve precision cancer care.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Media
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
adjuvant therapy
en_US
dc.subject
chemotherapy
en_US
dc.subject
circulating tumor cells
en_US
dc.subject
disseminated tumor cells
en_US
dc.subject
metastasis
en_US
dc.subject
liquid biopsy
en_US
dc.subject
clinical trial design
en_US
dc.title
Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Frontiers in Cell and Developmental Biology
ethz.journal.volume
10
en_US
ethz.journal.abbreviated
Front. Cell Dev. Biol.
ethz.pages.start
929893
en_US
ethz.size
20 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Tumor-lock: forbid the generation of circulating tumor cells
en_US
ethz.grant
Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity.
en_US
ethz.grant
SNF-Förderungsprofessur PP00P3_190077
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::09736 - Aceto, Nicola / Aceto, Nicola
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::09736 - Aceto, Nicola / Aceto, Nicola
ethz.grant.agreementno
101001652
ethz.grant.agreementno
801159-21
ethz.grant.agreementno
190077
ethz.grant.fundername
EC
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
H2020
ethz.grant.program
H2020
ethz.grant.program
SNF-Förderprofessuren Stufe 1
ethz.date.deposited
2022-07-21T03:30:42Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-07-22T13:38:49Z
ethz.rosetta.lastUpdated
2023-02-07T04:47:44Z
ethz.rosetta.versionExported
true
ethz.COinS
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