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dc.contributor.author
Gevaert, Andreas B.
dc.contributor.author
Wood, Nathanael
dc.contributor.author
Boen, Jente R.A.
dc.contributor.author
Davos, Constantinos H.
dc.contributor.author
Hansen, Dominique
dc.contributor.author
Hanssen, Henner
dc.contributor.author
Krenning, Guido
dc.contributor.author
Moholdt, Trine
dc.contributor.author
Osto, Elena
dc.contributor.author
Paneni, Francesco
dc.contributor.author
Pedretti, Roberto F.E.
dc.contributor.author
Plösch, Torsten
dc.contributor.author
Simonenko, Maria
dc.contributor.author
Bowen, T. Scott
dc.date.accessioned
2023-03-13T13:36:15Z
dc.date.available
2022-09-06T02:57:00Z
dc.date.available
2022-09-16T10:04:20Z
dc.date.available
2023-03-13T13:36:15Z
dc.date.issued
2022-11
dc.identifier.issn
2047-4873
dc.identifier.issn
2047-4881
dc.identifier.other
10.1093/eurjpc/zwac179
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/568893
dc.identifier.doi
10.3929/ethz-b-000568893
dc.description.abstract
Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
DNA methylation
en_US
dc.subject
Histone modification
en_US
dc.subject
Non-coding RNA
en_US
dc.subject
Epigenetic editing
en_US
dc.subject
RNA therapeutics
en_US
dc.subject
Heart failure
en_US
dc.subject
Coronary artery disease
en_US
dc.subject
Hypertension
en_US
dc.subject
Physical activity
en_US
dc.title
Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2022-08-22
ethz.journal.title
European Journal of Preventive Cardiology
ethz.journal.volume
29
en_US
ethz.journal.issue
17
en_US
ethz.journal.abbreviated
Eur J Prev Cardiolog
ethz.pages.start
2183
en_US
ethz.pages.end
2199
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-09-06T02:57:59Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-03-13T13:36:16Z
ethz.rosetta.lastUpdated
2024-02-02T20:58:02Z
ethz.rosetta.versionExported
true
ethz.COinS
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