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dc.contributor.author
Mwangi, Martin N.
dc.contributor.author
Oonincx, Dennis G. A. B.
dc.contributor.author
Hummel, Marijke
dc.contributor.author
Utami, Dessy A.
dc.contributor.author
Gunawan, Lidyawati
dc.contributor.author
Veenenbos, Margot
dc.contributor.author
Zeder, Christophe
dc.contributor.author
Cercamondi, Colin I.
dc.contributor.author
Zimmermann, Michael B.
dc.contributor.author
van Loon, Joop J. A.
dc.contributor.author
Dicke, Marcel
dc.contributor.author
Melse-Boonstra, Alida
dc.date.accessioned
2022-09-26T12:13:43Z
dc.date.available
2022-09-22T03:34:31Z
dc.date.available
2022-09-26T12:13:43Z
dc.date.issued
2022
dc.identifier.issn
0002-9165
dc.identifier.issn
1938-3207
dc.identifier.other
10.1093/ajcn/nqac223
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/572252
dc.identifier.doi
10.3929/ethz-b-000572252
dc.description.abstract
Background Edible insects are a novel source of animal protein. Moreover, edible insects contain iron concentrations similar to meat, potentially making them a valuable iron source for human consumers. Yet, it is unknown to what extent iron from insects is absorbed in humans. Objectives In this exploratory study, we assessed fractional iron absorption from house crickets (Acheta domesticus) consumed with refined (low-phytate, noninhibiting) or nonrefined (high-phytate, inhibiting) meals. Methods Intrinsically [57Fe]-labeled and control crickets were reared. Six iron-balanced experimental meals were randomly administered crossover to 20 iron-depleted females (serum ferritin <25 µg/L; 18–30 y old), in 2 time-blocks of 3 consecutive days, 2 wk apart. Three meals consisted of refined maize flour porridge with either [57Fe]-labeled crickets, [58Fe]SO4 (reference meal), or unlabeled crickets plus [54Fe]SO4. The other 3 meals consisted of nonrefined maize flour porridge with the same respective additions. Blood samples were drawn to assess the 14-d isotope enrichment in erythrocytes, and meal-specific fractional iron absorption was calculated. In vitro digestion was used to explore possible explanations for unexpected findings. Results Mean fractional iron absorption from 57Fe-labeled house crickets with refined maize porridge (3.06%) and from refined maize porridge with unlabeled crickets (4.92%) was lower than from the reference meal (14.2%), with respective mean differences of −11.1% (95% CI: −12.6%, −9.68%) and −9.29% (95% CI: −10.8%, −7.77%). Iron absorption from all meals based on unrefined maize porridge was low (<3%), and did not differ for the 2 meals with crickets compared with the reference meal. In vitro digestion showed that chitin, chitosan, and calcium limited iron bioaccessibility to a large extent. Conclusions Iron absorption from house crickets and fortified maize porridge with crickets is low, which may be explained by the presence of chitin and other inhibitors in the cricket biomass.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
iron
en_US
dc.subject
edible insects
en_US
dc.subject
Acheta domestica
en_US
dc.subject
stable isotopes
en_US
dc.subject
fractional iron absorption
en_US
dc.subject
bioavailability
en_US
dc.subject
chitin
en_US
dc.subject
anemia
en_US
dc.subject
human
en_US
dc.subject
Netherlands
en_US
dc.title
Absorption of iron from edible house crickets: a randomized crossover stable-isotope study in humans
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2022-08-26
ethz.journal.title
The American Journal of Clinical Nutrition
ethz.journal.abbreviated
Am J Clin Nutr
ethz.pages.start
nqac223
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2022-09-22T03:35:13Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2022-09-26T12:13:45Z
ethz.rosetta.lastUpdated
2022-09-26T12:13:45Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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