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dc.contributor.author
Josse, Andrea R.
dc.contributor.author
Garcia-Bailo, Bibiana
dc.contributor.author
Fischer, Karina
dc.contributor.author
El-Sohemy, Ahmed
dc.date.accessioned
2018-09-20T10:42:10Z
dc.date.available
2017-06-10T10:12:39Z
dc.date.available
2018-09-20T10:42:10Z
dc.date.issued
2012-09-12
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0045162
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/57366
dc.identifier.doi
10.3929/ethz-b-000057366
dc.description.abstract
Background Hormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear. Objectives To determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways. Method Concentrations of 54 high-abundance plasma proteins were measured simultaneously by LC-MRM/MS in 783 women from the Toronto Nutrigenomics and Health Study. C-reactive protein (CRP) was measured separately. ANCOVA was used to test differences in protein concentrations between users and non-users, and among HC users depending on total hormone dose. Linear regression was used to test the association between duration (years) of HC use and plasma protein concentrations. Principal components analysis (PCA) was used to identify plasma proteomic profiles in users and non-users. Results After Bonferroni correction, 19 proteins involved in inflammation, innate immunity, coagulation and blood pressure regulation were significantly different between users and non-users (P<0.0009). These differences were replicated across three distinct ethnocultural groups. Traditional markers of glucose and lipid metabolism were also significantly higher among HC users. Neither hormone dose nor duration of use affected protein concentrations. PCA identified 4 distinct proteomic profiles in users and 3 in non-users. Conclusion HC use was associated with different concentrations of plasma proteins along various disease-related pathways, and these differences were present across different ethnicities. Aside from the known effect of HC on traditional biomarkers of cardiometabolic risk, HC use also affects numerous proteins that may be biomarkers of dysregulation in inflammation, coagulation and blood pressure.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Novel Effects of Hormonal Contraceptive Use on the Plasma Proteome
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS ONE
ethz.journal.volume
7
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e45162
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006206116
ethz.publication.place
Lawrence, KS, USA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-10T10:15:18Z
ethz.source
ECIT
ethz.identifier.importid
imp59364fe6129bb70852
ethz.ecitpid
pub:91880
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T15:21:22Z
ethz.rosetta.lastUpdated
2021-02-15T01:49:16Z
ethz.rosetta.versionExported
true
ethz.COinS
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