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dc.contributor.author
Eyles, Darryl Walter
dc.contributor.author
Feldon, Joram
dc.contributor.author
Meyer, Urs
dc.date.accessioned
2019-08-23T13:50:13Z
dc.date.available
2017-06-10T10:14:55Z
dc.date.available
2019-08-23T13:50:13Z
dc.date.issued
2012
dc.identifier.issn
2158-3188
dc.identifier.other
10.1038/tp.2012.6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/57448
dc.identifier.doi
10.3929/ethz-b-000057448
dc.description.abstract
The idea that there is some sort of abnormality in dopamine (DA) signalling is one of the more enduring hypotheses inschizophrenia research. Opinion leaders have published recent perspectives on the aetiology of this disorder with provocativetitles such as ‘Risk factors for schizophrenia—all roads lead to dopamine’ or ‘The dopamine hypothesis of schizophrenia—thefinal common pathway’. Perhaps, the other most enduring idea about schizophrenia is that it is a neurodevelopmental disorder.Those of us that model schizophrenia developmental risk-factor epidemiology in animals in an attempt to understand how thismay translate to abnormal brain function have consistently shown that as adults these animals display behavioural, cognitiveand pharmacological abnormalities consistent with aberrant DA signalling. The burning question remains how canin uteroexposure to specific (environmental) insults induce persistent abnormalities in DA signalling in the adult? In this review, wesummarize convergent evidence from two well-described developmental animal models, namely maternal immune activation anddevelopmental vitamin D deficiency that begin to address this question. The adult offspring resulting from these two modelsconsistently reveal locomotor abnormalities in response to DA-releasing or -blocking drugs. Additionally, as adults theseanimals have DA-related attentional and/or sensorimotor gating deficits. These findings are consistent with many otherdevelopmental animal models. However, the authors of this perspective have recently refocused their attention on very earlyaspects of DA ontogeny and describe reductions in genes that induce or specify dopaminergic phenotype in the embryonic brainand early changes in DA turnover suggesting that the origins of these behavioural abnormalities in adults may be traced to earlyalterations in DA ontogeny. Whether the convergent findings from these two models can be extended to other developmentalanimal models for this disease is at present unknown as such early brain alterations are rarely examined. Although it ispremature to conclude that such mechanisms could be operating in other developmental animal models for schizophrenia, ourconvergent data have led us to propose that rather than all roads leading to DA, perhaps, this may be where they start.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title
Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2012-02-21
ethz.journal.title
Translational Psychiatry
ethz.journal.volume
2
en_US
ethz.journal.abbreviated
Transl Psychiatr
ethz.pages.start
e81
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03274 - Langhans, Wolfgang (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03274 - Langhans, Wolfgang (emeritus)
ethz.date.deposited
2017-06-10T10:15:18Z
ethz.source
ECIT
ethz.identifier.importid
imp59364fe7731aa38313
ethz.ecitpid
pub:91971
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T06:28:05Z
ethz.rosetta.lastUpdated
2019-08-23T13:50:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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