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dc.contributor.author
Dogan, Nihal Olcay
dc.contributor.author
Ceylan, Hakan
dc.contributor.author
Suadiye, Eylül
dc.contributor.author
Sheehan, Devin
dc.contributor.author
Aydin, Asli
dc.contributor.author
Yasa, Immihan Ceren
dc.contributor.author
Wild, Anna-Maria
dc.contributor.author
Richter, Gunther
dc.contributor.author
Sitti, Metin
dc.date.accessioned
2023-03-22T12:50:45Z
dc.date.available
2022-10-14T06:12:07Z
dc.date.available
2022-10-18T09:00:15Z
dc.date.available
2023-03-22T12:50:45Z
dc.date.issued
2022-11-17
dc.identifier.issn
1613-6810
dc.identifier.issn
1613-6829
dc.identifier.other
10.1002/smll.202204016
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/575928
dc.identifier.doi
10.3929/ethz-b-000575928
dc.description.abstract
Building medical microrobots from the body's own cells may circumvent the biocompatibility concern and hence presents more potential in clinical applications to improve the possibility of escaping from the host defense mechanism. More importantly, live cells can enable therapeutically relevant functions with significantly higher efficiency than synthetic systems. Here, live immune cell-derived microrobots from macrophages, i.e., immunobots, which can be remotely steered with externally applied magnetic fields and directed toward anti-tumorigenic (M1) phenotypes, are presented. Macrophages engulf the engineered magnetic decoy bacteria, composed of 0.5 mu m diameter silica Janus particles with one side coated with anisotropic FePt magnetic nanofilm and the other side coated with bacterial lipopolysaccharide (LPS). This study demonstrates the torque-based surface rolling locomotion of the immunobots along assigned trajectories inside blood plasma, over a layer of endothelial cells, and under physiologically relevant flow rates. The immunobots secrete signature M1 cytokines, IL-12 p40, TNF-alpha, and IL-6, and M1 cell markers, CD80 and iNOS, via toll-like receptor 4 (TLR4)-mediated stimulation with bacterial LPS. The immunobots exhibit anticancer activity against urinary bladder cancer cells. This study further demonstrates such immunobots from freshly isolated primary bone marrow-derived macrophages since patient-derivable macrophages may have a strong clinical potential for future cell therapies in cancer.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-VCH
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
cancer immunotherapy
en_US
dc.subject
cell-based microrobots
en_US
dc.subject
immune cells
en_US
dc.subject
immunomodulation
en_US
dc.subject
macrophages
en_US
dc.title
Remotely Guided Immunobots Engaged in Anti-Tumorigenic Phenotypes for Targeted Cancer Immunotherapy
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2022-10-06
ethz.journal.title
Small
ethz.journal.volume
18
en_US
ethz.journal.issue
46
en_US
ethz.pages.start
2204016
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::09726 - Sitti, Metin (ehemalig) / Sitti, Metin (former)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::09726 - Sitti, Metin (ehemalig) / Sitti, Metin (former)
ethz.date.deposited
2022-10-14T06:12:18Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-03-22T12:50:47Z
ethz.rosetta.lastUpdated
2024-02-02T21:15:48Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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