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dc.contributor.author
Vertes, Robert P.
dc.contributor.author
Hoover, Walter B.
dc.contributor.author
Witter, Menno P.
dc.contributor.author
Yanik, Mehmet Fatih
dc.contributor.author
Rojas, Amanda K.P.
dc.contributor.author
Linley, Stephanie B.
dc.date.accessioned
2023-03-17T11:02:11Z
dc.date.available
2022-10-20T03:21:25Z
dc.date.available
2022-10-21T11:14:11Z
dc.date.available
2022-10-25T07:45:19Z
dc.date.available
2023-03-17T11:02:11Z
dc.date.issued
2023-02
dc.identifier.issn
0021-9967
dc.identifier.issn
1096-9861
dc.identifier.issn
0092-7317
dc.identifier.other
10.1002/cne.25419
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/576935
dc.description.abstract
The orbital cortex (ORB) of the rat consists of five divisions: the medial (MO), ventral (VO), ventrolateral (VLO), lateral (LO), and dorsolateral (DLO) orbital cortices. No previous report has comprehensively examined and compared projections from each division of the ORB to the thalamus. Using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin, we describe the efferent projections from the five divisions of the ORB to the thalamus in the rat. We demonstrated that, with some overlap, each division of the ORB distributed in a distinct (and unique) manner to nuclei of the thalamus. Overall, ORB projected to a relatively restricted number of sites in the thalamus, and strikingly distributed entirely to structures of the medial/midline thalamus, while completely avoiding lateral regions or principal nuclei of the thalamus. The main termination sites in the thalamus were the paratenial nucleus (PT) and nucleus reuniens (RE) of the midline thalamus, the medial (MDm) and central (MDc) divisions of the mediodorsal nucleus, the intermediodorsal nucleus, the central lateral, paracentral, and central medial nuclei of the rostral intralaminar complex and the submedial nucleus (SM). With some exceptions, medial divisions of the ORB (MO, VO) mainly targeted "limbic-associated" nuclei such as PT, RE, and MDm, whereas lateral division (VLO, LO, DLO) primarily distributed to "sensorimotor-associated" nuclei including MDc, SM, and the rostral intralaminar complex. As discussed herein, the medial/midline thalamus may represent an important link (or bridge) between the orbital cortex and the hippocampus and between the ORB and medial prefrontal cortex. In summary, the present results demonstrate that each division of the orbital cortex projects in a distinct manner to nuclei of the thalamus which suggests unique functions for each division of the orbital cortex.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-Blackwell
en_US
dc.subject
behavioral flexibility
en_US
dc.subject
cognition
en_US
dc.subject
medial prefrontal cortex
en_US
dc.subject
mediodorsal nucleus
en_US
dc.subject
nucleus reuniens
en_US
dc.subject
paratenial nucleus
en_US
dc.subject
reversal learning
en_US
dc.title
Projections from the five divisions of the orbital cortex to the thalamus in the rat
en_US
dc.type
Journal Article
dc.date.published
2022-10-12
ethz.journal.title
The Journal of Comparative Neurology
ethz.journal.volume
531
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
J Comp Neurol
ethz.pages.start
217
en_US
ethz.pages.end
237
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::09474 - Yanik, Mehmet Fatih / Yanik, Mehmet Fatih
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::09474 - Yanik, Mehmet Fatih / Yanik, Mehmet Fatih
ethz.date.deposited
2022-10-20T03:21:29Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2023-03-17T11:02:13Z
ethz.rosetta.lastUpdated
2023-03-17T11:02:13Z
ethz.rosetta.versionExported
true
ethz.COinS
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