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dc.contributor.author
Gardiner, Donald M.
dc.contributor.author
McDonald, Megan C.
dc.contributor.author
Covarelli, Lorenzo
dc.contributor.author
Solomon, Peter S.
dc.contributor.author
Rusu, Anca G.
dc.contributor.author
Marshall, Mhairi
dc.contributor.author
Kazan, Kemal
dc.contributor.author
Chakraborty, Sukumar
dc.contributor.author
McDonald, Bruce A.
dc.contributor.author
Manners, John M.
dc.date.accessioned
2018-11-27T11:11:03Z
dc.date.available
2017-06-10T10:26:20Z
dc.date.available
2018-11-06T11:30:42Z
dc.date.available
2018-11-27T11:11:03Z
dc.date.issued
2012-09-27
dc.identifier.issn
1553-7374
dc.identifier.issn
1553-7366
dc.identifier.other
10.1371/journal.ppat.1002952
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/57696
dc.identifier.doi
10.3929/ethz-b-000057696
dc.description.abstract
Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases of wheat and barley world-wide. In Australia, these diseases are primarily caused by the fungal pathogen Fusarium pseudograminearum. Comparative genomic analyses showed that the F. pseudograminearum genome encodes proteins that are present in other fungal pathogens of cereals but absent in non-cereal pathogens. In some cases, these cereal pathogen specific genes were also found in bacteria associated with plants. Phylogenetic analysis of selected F. pseudograminearum genes supported the hypothesis of horizontal gene transfer into diverse cereal pathogens. Two horizontally acquired genes with no previously known role in fungal pathogenesis were studied functionally via gene knockout methods and shown to significantly affect virulence of F. pseudograminearum on the cereal hosts wheat and barley. Our results indicate using comparative genomics to identify genes specific to pathogens of related hosts reveals novel virulence genes and illustrates the importance of horizontal gene transfer in the evolution of plant infecting fungal pathogens.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
PLOS
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Comparative Pathogenomics Reveals Horizontally Acquired Novel Virulence Genes in Fungi Infecting Cereal Hosts
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS Pathogens
ethz.journal.volume
8
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
PLoS Pathog
ethz.pages.start
e1002952
en_US
ethz.size
22 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Lawrence, KS
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.date.deposited
2017-06-10T10:28:41Z
ethz.source
ECIT
ethz.identifier.importid
imp59364febcecc688864
ethz.ecitpid
pub:92345
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T18:58:16Z
ethz.rosetta.lastUpdated
2024-02-02T06:41:11Z
ethz.rosetta.versionExported
true
ethz.COinS
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