The Adaptive Potential of Nonheritable Somatic Mutations
dc.contributor.author
Majic, Paco
dc.contributor.author
Erten, E. Yagmur
dc.contributor.author
Payne, Joshua L.
dc.date.accessioned
2023-03-10T09:43:27Z
dc.date.available
2022-11-04T06:46:17Z
dc.date.available
2022-11-04T11:44:39Z
dc.date.available
2023-03-10T09:43:27Z
dc.date.issued
2022-12
dc.identifier.issn
0003-0147
dc.identifier.issn
1537-5323
dc.identifier.other
10.1086/721766
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/579348
dc.identifier.doi
10.3929/ethz-b-000579348
dc.description.abstract
The adaptive potential of nonheritable somatic mutations has received limited attention in traditional evolutionary theory because heritability is a fundamental pillar of Darwinian evolution. We hypothesized that the ability of a germline genotype to express a novel phenotype via nonheritable somatic mutations can be selectively advantageous and that this advantage will channel evolving populations toward germline genotypes that constitutively express the phenotype. We tested this hypothesis by simulating evolving populations of developing organisms with an impermeable germline-soma separation navigating a minimal fitness landscape. The simulations revealed the conditions under which nonheritable somatic mutations promote adaptation. Specifically, this can occur when the somatic mutation supply is high, when few cells with the advantageous somatic mutation are required to increase organismal fitness, and when the somatic mutation also confers a selective advantage at the cellular level. We therefore provide proof of principle that nonheritable somatic mutations can promote adaptive evolution via a process we call "somatic genotypic exploration." We discuss the biological plausibility of this phenomenon as well as its evolutionary implications.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
University of Chicago Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
somatic mutations
en_US
dc.subject
Weissman
en_US
dc.subject
evolutionary theory
en_US
dc.subject
development
en_US
dc.subject
adaptive landscape
en_US
dc.subject
multilevel selection
en_US
dc.title
The Adaptive Potential of Nonheritable Somatic Mutations
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2022-10-07
ethz.journal.title
The American Naturalist
ethz.journal.volume
200
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Amer Natur
ethz.pages.start
755
en_US
ethz.pages.end
772
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Regulatory logic and the evolution of promoter complexity
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Chicago, IL
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::09613 - Payne, Joshua (ehemalig) / Payne, Joshua (former)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::09613 - Payne, Joshua (ehemalig) / Payne, Joshua (former)
ethz.grant.agreementno
170604
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
SNF-Förderungsprofessuren Stufe 2
ethz.date.deposited
2022-11-04T06:46:37Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-03-10T09:43:28Z
ethz.rosetta.lastUpdated
2024-02-02T20:50:45Z
ethz.rosetta.versionExported
true
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