Multimodal imaging of human cerebellum

Open access
Author
Schulz, Georg
Waschkies, Conny
Pfeiffer, Franz
Zanette, Irene
Weitkamp, Timm
David, Christian
Müller, Bert
Date
2012-11-09Type
- Journal Article
Abstract
Imaging modalities including magnetic resonance imaging and X-ray computed tomography are established methods in daily clinical diagnosis of human brain. Clinical equipment does not provide sufficient spatial resolution to obtain morphological information on the cellular level, essential for applying minimally or non-invasive surgical interventions. Therefore, generic data with lateral sub-micrometer resolution have been generated from histological slices post mortem. Sub-cellular spatial resolution, lost in the third dimension as a result of sectioning, is obtained using magnetic resonance microscopy and micro computed tomography. We demonstrate that for human cerebellum grating-based X-ray phase tomography shows complementary contrast to magnetic resonance microscopy and histology. In this study, the contrast-to-noise values of magnetic resonance microscopy and phase tomography were comparable whereas the spatial resolution in phase tomography is an order of magnitude better. The registered data with their complementary information permit the distinct segmentation of tissues within the human cerebellum Show more
Permanent link
https://doi.org/10.3929/ethz-b-000058696Publication status
publishedJournal / series
Scientific ReportsVolume
Pages / Article No.
Publisher
Nature Publishing GroupSubject
Structure of solids and liquids; Brain; Biophysics; Biomedical engineeringMore
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