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dc.contributor.author
Schulz, Georg
dc.contributor.author
Waschkies, Conny
dc.contributor.author
Pfeiffer, Franz
dc.contributor.author
Zanette, Irene
dc.contributor.author
Weitkamp, Timm
dc.contributor.author
David, Christian
dc.contributor.author
Müller, Bert
dc.date.accessioned
2018-09-10T15:13:11Z
dc.date.available
2017-06-10T11:11:14Z
dc.date.available
2018-09-10T15:13:11Z
dc.date.issued
2012-11-09
dc.identifier.other
10.1038/srep00826
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/58696
dc.identifier.doi
10.3929/ethz-b-000058696
dc.description.abstract
Imaging modalities including magnetic resonance imaging and X-ray computed tomography are established methods in daily clinical diagnosis of human brain. Clinical equipment does not provide sufficient spatial resolution to obtain morphological information on the cellular level, essential for applying minimally or non-invasive surgical interventions. Therefore, generic data with lateral sub-micrometer resolution have been generated from histological slices post mortem. Sub-cellular spatial resolution, lost in the third dimension as a result of sectioning, is obtained using magnetic resonance microscopy and micro computed tomography. We demonstrate that for human cerebellum grating-based X-ray phase tomography shows complementary contrast to magnetic resonance microscopy and histology. In this study, the contrast-to-noise values of magnetic resonance microscopy and phase tomography were comparable whereas the spatial resolution in phase tomography is an order of magnitude better. The registered data with their complementary information permit the distinct segmentation of tissues within the human cerebellum.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject
Structure of solids and liquids
en_US
dc.subject
Brain
en_US
dc.subject
Biophysics
en_US
dc.subject
Biomedical engineering
en_US
dc.title
Multimodal imaging of human cerebellum
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
ethz.title.subtitle
Merging X-ray phase microtomography, magnetic resonance microscopy and histology
en_US
ethz.journal.title
Scientific Reports
ethz.journal.volume
2
en_US
ethz.pages.start
826
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006751867
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-10T11:11:47Z
ethz.source
ECIT
ethz.identifier.importid
imp593650008bd0582659
ethz.ecitpid
pub:93911
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T14:24:16Z
ethz.rosetta.lastUpdated
2019-01-02T13:51:49Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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