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dc.contributor.author
Peereboom, Sophie M.
dc.contributor.author
Guenthner, Christian
dc.contributor.author
Albannay, Mohammed
dc.contributor.author
Kozerke, Sebastian
dc.date.accessioned
2023-01-26T14:24:16Z
dc.date.available
2023-01-25T04:43:45Z
dc.date.available
2023-01-26T14:24:16Z
dc.date.issued
2023
dc.identifier.issn
0952-3480
dc.identifier.issn
1099-1492
dc.identifier.other
10.1002/nbm.4892
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/594616
dc.description.abstract
Recent work on high-performance lower-field MR systems has renewed the interest in assessing relative advantages and disadvantages of magnetic fields less than 1 T. The objective of the present work was to investigate signal-to-noise ratio (SNR) scaling of point-resolved spectroscopy as a function of field strength and to test the feasibility of proton MRS of triglycerides (TGs) in human in vivo myocardium at 0.75 T relative to 1.5 T and 3 T. Measurements at 0.75 T were obtained by temporarily ramping down a clinical 3 T MR scanner. System configurations at 0.75, 1.5 and 3 T featured identical hard- and software, except for differences in transmit/receive coil geometries and receive channel count, which were accounted for in SNR comparisons. Proton MRS was performed at 0.75 T, 1.5 T and 3 T in ex vivo tissue and in vivo calf muscle to measure T-1 and T-2 values as a function of field strength, which in turn served as input to simulations of SNR scaling and field-dependent TG fit errors. Preliminary in vivo spectra of myocardium were acquired at 0.75 T, 1.5 T and 3 T in healthy subjects. Measurements of both ex vivo tissue and in vivo muscle tissue at 0.75 T versus 1.5 T and 3 T confirmed decreasing T-1 and increasing T-2* for decreasing field strengths. Using measured T-1, T-2 and T-2* as input and using field-dependent echo time and bandwidth scaling, simulated Cramer-Rao lower bounds of TG amplitudes at 0.75 T were 2.3 and 4.5 times larger with respect to 1.5 T and 3 T, respectively. In vivo measurements demonstrate that human proton spectroscopy of TGs in cardiac muscle is feasible at 0.75 T, supporting the potential practical value of lower-field high-performance MR systems.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
cardiac muscle
en_US
dc.subject
heart
en_US
dc.subject
lower-field MR
en_US
dc.subject
PRESS
en_US
dc.subject
proton spectroscopy
en_US
dc.subject
triglyceride
en_US
dc.title
Preliminary experience of cardiac proton spectroscopy at 0.75 T
en_US
dc.type
Journal Article
dc.date.published
2022-12-12
ethz.journal.title
NMR in Biomedicine
ethz.journal.abbreviated
NMR Biomed
ethz.pages.start
e4892
en_US
ethz.size
14 p.
en_US
ethz.identifier.wos
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2023-01-25T04:43:46Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.exportRequired
true
ethz.COinS
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