The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition
dc.contributor.author
Felley-Bosco, Emanuela
dc.contributor.author
Qi, Weihong
dc.contributor.author
Jean, Didier
dc.contributor.author
Meiller, Clément
dc.contributor.author
Rehrauer, Hubert
dc.date.accessioned
2023-02-24T09:23:02Z
dc.date.available
2023-02-24T04:57:24Z
dc.date.available
2023-02-24T09:23:02Z
dc.date.issued
2023-02-01
dc.identifier.issn
1422-0067
dc.identifier.other
10.3390/ijms24032874
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/600385
dc.identifier.doi
10.3929/ethz-b-000600385
dc.description.abstract
Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3′UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Pleural mesothelioma
en_US
dc.subject
RNA editing
en_US
dc.subject
Epithelial-to-mesenchymal transition
en_US
dc.title
The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2023-02-02
ethz.journal.title
International Journal of Molecular Sciences
ethz.journal.volume
24
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
Int. j. mol. sci.
ethz.pages.start
2874
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.date.deposited
2023-02-24T04:57:25Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-02-24T09:23:03Z
ethz.rosetta.lastUpdated
2024-02-02T20:07:44Z
ethz.rosetta.versionExported
true
ethz.COinS
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Journal Article [133071]