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dc.contributor.author
Harms, Alexander
dc.contributor.author
Stanger, Frédéric V.
dc.contributor.author
Dehio, Christoph
dc.date.accessioned
2023-03-21T07:41:21Z
dc.date.available
2023-03-19T19:34:07Z
dc.date.available
2023-03-21T07:41:21Z
dc.date.issued
2016
dc.identifier.issn
0066-4227
dc.identifier.issn
1545-3251
dc.identifier.other
10.1146/annurev-micro-102215-095245
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/603800
dc.description.abstract
The ubiquitous proteins with FIC (filamentation induced by cyclic AMP) domains use a conserved enzymatic machinery to modulate the activity of various target proteins by posttranslational modification, typically AMPylation. Following intensive study of the general properties of FIC domain catalysis, diverse molecular activities and biological functions of these remarkably versatile proteins are now being revealed. Here, we review the biological diversity of FIC domain proteins and summarize the underlying structure-function relationships. The original and most abundant genuine bacterial FIC domain proteins are toxins that use diverse molecular activities to interfere with bacterial physiology in various, yet ill-defined, biological contexts. Host-targeted virulence factors have evolved repeatedly out of this pool by exaptation of the enzymatic FIC domain machinery for the manipulation of host cell signaling in favor of bacterial pathogens. The single human FIC domain protein HypE (FICD) has a specific function in the regulation of protein stress responses.
en_US
dc.language.iso
en
en_US
dc.publisher
Annual Reviews
en_US
dc.subject
AMPylation
en_US
dc.subject
Adenylylation
en_US
dc.subject
Posttranslational modification
en_US
dc.subject
Toxin-antitoxin modules
en_US
dc.subject
Bacterial effector protein
en_US
dc.subject
Bacterial evolution
en_US
dc.title
Biological Diversity and Molecular Plasticity of FIC Domain Proteins
en_US
dc.type
Review Article
ethz.journal.title
Annual Review of Microbiology
ethz.journal.volume
70
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Ann. Rev. Microbiol.
ethz.pages.start
341
en_US
ethz.pages.end
360
en_US
ethz.publication.place
Palo Alto, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::09807 - Harms, Alexander / Harms, Alexande
en_US
ethz.date.deposited
2023-03-19T19:34:08Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2023-03-21T07:41:22Z
ethz.rosetta.lastUpdated
2024-02-02T21:13:35Z
ethz.rosetta.versionExported
true
ethz.COinS
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