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dc.contributor.author
Harms, Alexander
dc.contributor.author
Maisonneuve, Etienne
dc.contributor.author
Gerdes, Kenn
dc.date.accessioned
2023-03-20T14:38:20Z
dc.date.available
2023-03-19T19:37:46Z
dc.date.available
2023-03-20T14:38:20Z
dc.date.issued
2016-12-16
dc.identifier.issn
0036-8075
dc.identifier.issn
1095-9203
dc.identifier.other
10.1126/science.aaf4268
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/603803
dc.description.abstract
Bacterial persister cells avoid antibiotic-induced death by entering a physiologically dormant state and are considered a major cause of antibiotic treatment failure and relapsing infections. Such dormant cells form stochastically, but also in response to environmental cues, by various pathways that are usually controlled by the second messenger (p)ppGpp. For example, toxin-antitoxin modules have been shown to play a major role in persister formation in many model systems. More generally, the diversity of molecular mechanisms driving persister formation is increasingly recognized as the cause of physiological heterogeneity that underlies collective multistress and multidrug tolerance of persister subpopulations. In this Review, we summarize the current state of the field and highlight recent findings, with a focus on the molecular basis of persister formation and heterogeneity.
en_US
dc.language.iso
en
en_US
dc.publisher
AAAS
en_US
dc.title
Mechanisms of bacterial persistence during stress and antibiotic exposure
en_US
dc.type
Review Article
ethz.journal.title
Science
ethz.journal.volume
354
en_US
ethz.journal.issue
6318
en_US
ethz.pages.start
aaf4268
en_US
ethz.size
10 p.
en_US
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::09807 - Harms, Alexander / Harms, Alexande
en_US
ethz.date.deposited
2023-03-19T19:37:47Z
ethz.source
FORM
ethz.eth
no
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2023-03-20T14:38:21Z
ethz.rosetta.lastUpdated
2024-02-02T21:13:02Z
ethz.rosetta.versionExported
true
ethz.COinS
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