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dc.contributor.author
Zimmermann, Monika
dc.contributor.author
Gerken, Lukas R.H.
dc.contributor.author
Wee, Shianlin
dc.contributor.author
Kissling, Vera M.
dc.contributor.author
Neuer, Anna Lena
dc.contributor.author
Tsolaki, Elena
dc.contributor.author
Gogos, Alexander
dc.contributor.author
Lukatskaya, Maria
dc.contributor.author
Herrmann, Inge
dc.date.accessioned
2023-04-06T11:36:42Z
dc.date.available
2023-03-31T11:03:24Z
dc.date.available
2023-04-03T13:21:36Z
dc.date.available
2023-04-06T11:36:42Z
dc.date.issued
2023-03-30
dc.identifier.issn
2573-2293
dc.identifier.other
10.26434/chemrxiv-2023-j8hmc
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/606021
dc.identifier.doi
10.3929/ethz-b-000606021
dc.description.abstract
Radiotherapy is an integral part of cancer therapy. Due to the low tissue specificity of radiation, damage to tumor-surrounding healthy tissue remains a major concern. Radio-enhancers based on inorganic nanomaterials have attracted considerable attention in recent years. In addition to widely exploited metal and metal oxides nanoparticles, 2D materials may offer potential advantages due to their intrinsically high specific surface area. Here, we report on the promising radio-enhancement properties of Ti3C2Tx MXenes. We show that Ti3C2Tx MXenes are readily internalized and well-tolerated by mammalian cells. In contrast to MXenes suspended in aqueous buffers which fully oxidize within days (yielding rice-grain shaped rutile nanoparticles), MXenes internalized by cells display slower oxidation rates, in line with cell-free experiments showing slower oxidation in cell media and lysosomal buffers compared to antioxidant-devoid dispersants. The MXenes show potent radio-enhancement properties with dose enhancement factors of up to 2.5 in human soft tissue sarcoma cells and no toxicity towards healthy human fibroblasts. Benchmarking against oxidized MXenes and commercial titanium dioxide nanoparticles indicates superior radio-enhancement properties of the intact 2D titanium carbide flakes. Taken together, this work provides direct evidence for the potent radio-enhancement properties of Ti3C2Tx MXenes rendering them a promising candidate material for radiotherapy enhancement.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cambridge University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Radiotherapy Enhancement by Ti3C2Tx MXenes
en_US
dc.type
Working Paper
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
ChemRxiv
ethz.size
30 p.
en_US
ethz.grant
Catalytically Active Nanoparticle Radioenhancers
en_US
ethz.grant
Integrative Engineering of Metal Oxide Nanohybrid-based Surgical Adhesives: From Particle Design to Performance Assessment by Multiscale Analytics
en_US
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::09675 - Herrmann, Inge Katrin (ehemalig) / Herrmann, Inge Katrin (former)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02668 - Inst. f. Energie- und Verfahrenstechnik / Inst. Energy and Process Engineering::09675 - Herrmann, Inge Katrin (ehemalig) / Herrmann, Inge Katrin (former)
en_US
ethz.grant.agreementno
ETH-07 21-2
ethz.grant.agreementno
181290
ethz.grant.fundername
ETHZ
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100003006
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
ETH Grants
ethz.grant.program
Eccellenza
ethz.date.deposited
2023-03-31T11:03:24Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-04-03T13:21:37Z
ethz.rosetta.lastUpdated
2024-02-02T21:32:24Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Radiotherapy%20Enhancement%20by%20Ti3C2Tx%20MXenes&rft.jtitle=ChemRxiv&rft.date=2023-03-30&rft.issn=2573-2293&rft.au=Zimmermann,%20Monika&Gerken,%20Lukas%20R.H.&Wee,%20Shianlin&Kissling,%20Vera%20M.&Neuer,%20Anna%20Lena&rft.genre=preprint&rft_id=info:doi/10.26434/chemrxiv-2023-j8hmc&
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