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dc.contributor.author
Thanarajah, Sharmili Edwin
dc.contributor.author
DiFeliceantonio, Alexander G.
dc.contributor.author
Albus, Kerstin
dc.contributor.author
Kuzmanovic, Bojana
dc.contributor.author
Rigoux, Lionel
dc.contributor.author
Iglesias, Sandra
dc.contributor.author
Hanßen, Ruth
dc.contributor.author
Schlamann, Marc
dc.contributor.author
Cornely, Oliver A.
dc.contributor.author
Brüning, Jens C.
dc.contributor.author
Tittgemeyer, Marc
dc.contributor.author
Small, Dana M.
dc.date.accessioned
2023-04-12T07:50:45Z
dc.date.available
2023-04-11T16:58:16Z
dc.date.available
2023-04-12T07:50:45Z
dc.date.issued
2023-04-04
dc.identifier.issn
1550-4131
dc.identifier.issn
1932-7420
dc.identifier.other
10.1016/j.cmet.2023.02.015
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/607282
dc.identifier.doi
10.3929/ethz-b-000607282
dc.description.abstract
Western diets rich in fat and sugar promote excess calorie intake and weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity and altered brain dopamine function, it remains elusive whether these alterations are (1) pre-existing, increasing the individual susceptibility to weight gain, (2) secondary to obesity, or (3) directly attributable to repeated exposure to western diet. To close this gap, we performed a randomized, controlled study (NCT05574660) with normal-weight participants exposed to a high-fat/high-sugar snack or a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The high-fat/high-sugar intervention decreased the preference for low-fat food while increasing brain response to food and associative learning independent of food cues or reward. These alterations were independent of changes in body weight and metabolic parameters, indicating a direct effect of high-fat, high-sugar foods on neurobehavioral adaptations that may increase the risk for overeating and weight gain.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
obesity
en_US
dc.subject
high-fat diet
en_US
dc.subject
dopamine
en_US
dc.subject
reinforcement learning
en_US
dc.subject
neural plasticity
en_US
dc.subject
reward
en_US
dc.subject
value
en_US
dc.subject
preference
en_US
dc.subject
taste
en_US
dc.subject
fMRI
en_US
dc.subject
prediction error
en_US
dc.title
Habitual daily intake of a sweet and fatty snack modulates reward processing in humans
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2023-03-22
ethz.journal.title
Cell Metabolism
ethz.journal.volume
35
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Cell Metab
ethz.pages.start
571
en_US
ethz.pages.end
584.e6
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge, MA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2023-04-11T16:58:17Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-04-12T07:50:46Z
ethz.rosetta.lastUpdated
2024-02-02T21:34:39Z
ethz.rosetta.versionExported
true
ethz.COinS
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