Impact of cell size on morphogen gradient precision
dc.contributor.author
Adelmann, Jan A.
dc.contributor.author
Vetter, Roman
dc.contributor.author
Iber, Dagmar
dc.date.accessioned
2023-06-07T08:52:04Z
dc.date.available
2023-05-13T06:42:29Z
dc.date.available
2023-06-07T08:52:04Z
dc.date.issued
2023-05
dc.identifier.issn
0950-1991
dc.identifier.issn
1477-9129
dc.identifier.other
10.1242/dev.201702
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/612003
dc.identifier.doi
10.3929/ethz-b-000612003
dc.description.abstract
Tissue patterning during embryonic development is remarkably precise. Here, we numerically determine the impact of the cell diameter, gradient length and the morphogen source on the variability of morphogen gradients. We show that the positional error increases with the gradient length relative to the size of the morphogen source, and with the square root of the cell diameter and the readout position. We provide theoretical explanations for these relationships, and show that they enable high patterning precision over developmental time for readouts that scale with expanding tissue domains, as observed in the Drosophila wing disc. Our analysis suggests that epithelial tissues generally achieve higher patterning precision with small cross-sectional cell areas. An extensive survey of measured apical cell areas shows that they are indeed small in developing tissues that are patterned by morphogen gradients. Enhanced precision may thus have led to the emergence of pseudostratification in epithelia, a phenomenon for which the evolutionary benefit had so far remained elusive.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Company of Biologists
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Morphogen gradient
en_US
dc.subject
Patterning
en_US
dc.subject
Precision
en_US
dc.subject
Development
en_US
dc.subject
Cell size
en_US
dc.title
Impact of cell size on morphogen gradient precision
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Development
ethz.journal.volume
150
en_US
ethz.journal.issue
10
en_US
ethz.journal.abbreviated
Development
ethz.pages.start
dev201702
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
A 3D Cell-Based Simulation Framework for Morphogenetic Problems
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
en_US
ethz.grant.agreementno
170930
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Interdisziplinäres Projekt
ethz.date.deposited
2023-05-13T06:42:30Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-06-07T08:52:05Z
ethz.rosetta.lastUpdated
2024-02-02T23:55:51Z
ethz.rosetta.versionExported
true
ethz.COinS
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Journal Article [133619]