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dc.contributor.author
Naghavian, Reza
dc.contributor.author
Faigle, Wolfgang
dc.contributor.author
Oldrati, Pietro
dc.contributor.author
Wang, Jian
dc.contributor.author
Toussaint, Nora Christina
dc.contributor.author
Qiu, Yuhan
dc.contributor.author
Medici, Gioele
dc.contributor.author
Wacker, Marcel
dc.contributor.author
Freudenmann, Lena K.
dc.contributor.author
Bonté, Pierre-Emmanuel
dc.contributor.author
Weller, Michael
dc.contributor.author
Regli, Luca
dc.contributor.author
Amigorena, Sebastian
dc.contributor.author
Rammensee, Hans-Georg
dc.contributor.author
Walz, Juliane S.
dc.contributor.author
Brugger, Silvio D.
dc.contributor.author
Mohme, Malte
dc.contributor.author
Zhao, Yingdong
dc.contributor.author
Sospedra, Mireia
dc.contributor.author
Neidert, Marian C.
dc.contributor.author
Martin, Roland
dc.date.accessioned
2023-06-07T10:44:06Z
dc.date.available
2023-06-07T03:16:00Z
dc.date.available
2023-06-07T10:44:06Z
dc.date.issued
2023-05-25
dc.identifier.issn
0028-0836
dc.identifier.issn
1476-4687
dc.identifier.other
10.1038/s41586-023-06081-w
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/615356
dc.identifier.doi
10.3929/ethz-b-000615356
dc.description.abstract
Microbial organisms have key roles in numerous physiological processes in the human body and have recently been shown to modify the response to immune checkpoint inhibitors1,2. Here we aim to address the role of microbial organisms and their potential role in immune reactivity against glioblastoma. We demonstrate that HLA molecules of both glioblastoma tissues and tumour cell lines present bacteria-specific peptides. This finding prompted us to examine whether tumour-infiltrating lymphocytes (TILs) recognize tumour-derived bacterial peptides. Bacterial peptides eluted from HLA class II molecules are recognized by TILs, albeit very weakly. Using an unbiased antigen discovery approach to probe the specificity of a TIL CD4+ T cell clone, we show that it recognizes a broad spectrum of peptides from pathogenic bacteria, commensal gut microbiota and also glioblastoma-related tumour antigens. These peptides were also strongly stimulatory for bulk TILs and peripheral blood memory cells, which then respond to tumour-derived target peptides. Our data hint at how bacterial pathogens and bacterial gut microbiota can be involved in specific immune recognition of tumour antigens. The unbiased identification of microbial target antigens for TILs holds promise for future personalized tumour vaccination approaches.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2023-05-17
ethz.journal.title
Nature
ethz.journal.volume
617
en_US
ethz.journal.issue
7962
en_US
ethz.pages.start
807
en_US
ethz.pages.end
817
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis
en_US
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02892 - NEXUS Personalized Health Technologies / NEXUS Personalized Health Technologies
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02892 - NEXUS Personalized Health Technologies / NEXUS Personalized Health Technologies
ethz.grant.agreementno
340733
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
FP7
ethz.date.deposited
2023-06-07T03:16:01Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-06-07T10:44:08Z
ethz.rosetta.lastUpdated
2024-02-02T23:56:12Z
ethz.rosetta.versionExported
true
ethz.COinS
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