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dc.contributor.author
Orsenigo, Fabrizio
dc.contributor.author
Giampietro, Costanza
dc.contributor.author
Ferrari, Aldo
dc.contributor.author
Corada, Monica
dc.contributor.author
Galaup, Ariane
dc.contributor.author
Sigismund, Sara
dc.contributor.author
Ristagno, Giuseppe
dc.contributor.author
Maddaluno, Luigi
dc.contributor.author
Koh, Gou Y.
dc.contributor.author
Franco, Davide
dc.contributor.author
Kurtcuoglu, Vartan
dc.contributor.author
Poulikakos, Dimos
dc.contributor.author
Baluk, Peter
dc.contributor.author
McDonald, Donald
dc.contributor.author
Lampugnani, Maria G.
dc.contributor.author
Dejana, Elisabetta
dc.date.accessioned
2018-09-06T11:24:31Z
dc.date.available
2017-06-10T13:32:37Z
dc.date.available
2018-09-06T11:24:31Z
dc.date.issued
2012
dc.identifier.other
10.1038/ncomms2199
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/62985
dc.identifier.doi
10.3929/ethz-b-000062985
dc.description.abstract
Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their permeability but whether organization and strength of their adherens junctions vary has not been demonstrated in vivo. Here we report that vascular endothelial cadherin, an endothelial specific adhesion protein located at adherens junctions, is phosphorylated in Y658 and Y685 in vivo in veins but not in arteries under resting conditions. This difference is due to shear stress-induced junctional Src activation in veins. Phosphorylated vascular endothelial-cadherin is internalized and ubiquitinated in response to permeability-increasing agents such as bradykinin and histamine. Inhibition of Src blocks vascular endothelial cadherin phosphorylation and bradykinin-induced permeability. Point mutation of Y658F and Y685F prevents vascular endothelial cadherin internalization, ubiquitination and an increase in permeability by bradykinin in vitro. Thus, phosphorylation of vascular endothelial cadherin contributes to a dynamic state of adherens junctions, but is not sufficient to increase vascular permeability in the absence of inflammatory agents.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2012-11-20
ethz.journal.title
Nature Communications
ethz.journal.volume
3
en_US
ethz.pages.start
1208
en_US
ethz.size
15 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02627 - Institut für Energietechnik / Institute of Energy Technology::03462 - Poulikakos, Dimos / Poulikakos, Dimos
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02130 - Dep. Maschinenbau und Verfahrenstechnik / Dep. of Mechanical and Process Eng.::02627 - Institut für Energietechnik / Institute of Energy Technology::03462 - Poulikakos, Dimos / Poulikakos, Dimos
ethz.date.deposited
2017-06-10T13:33:12Z
ethz.source
ECIT
ethz.identifier.importid
imp5936504e4d0ef51352
ethz.ecitpid
pub:99905
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T09:09:21Z
ethz.rosetta.lastUpdated
2019-02-03T05:25:26Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Phosphorylation%20of%20VE-cadherin%20is%20modulated%20by%20haemodynamic%20forces%20and%20contributes%20to%20the%20regulation%20of%20vascular%20permeability%20in%20vivo&rft.jtitle=Nature%20Communications&rft.date=2012&rft.volume=3&rft.spage=1208&rft.au=Orsenigo,%20Fabrizio&Giampietro,%20Costanza&Ferrari,%20Aldo&Corada,%20Monica&Galaup,%20Ariane&rft.genre=article&
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