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dc.contributor.author
Mapel, Xena Marie
dc.contributor.author
Hiltpold, Maya
dc.contributor.author
Lloret i Villas, Audald
dc.contributor.author
Pausch, Hubert
dc.contributor.editor
Veerkamp, R.F.
dc.contributor.editor
de Haas, Y.
dc.date.accessioned
2023-10-18T13:52:55Z
dc.date.available
2023-09-26T08:06:42Z
dc.date.available
2023-09-26T08:10:12Z
dc.date.available
2023-10-18T13:52:55Z
dc.date.issued
2022
dc.identifier.isbn
978-90-8686-940-4
en_US
dc.identifier.other
10.3920/978-90-8686-940-4_548
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/633550
dc.identifier.doi
10.3929/ethz-b-000633550
dc.description.abstract
Fertility is an essential component of the livestock industry. In cattle, numerous QTL for male reproductive success fall within regulatory regions. However, the effects of these loci have not been investigated in detail or on a large scale. Here, we assemble a sizeable cohort of mature bulls to detect expression quantitative trait loci (eQTL) and assess their effects on fertility-related genes. To do this, we sequenced genomes and total RNA from the testes of 72 bulls. We recovered 13,185,795 DNA sequence variants with minor allele frequency >5%, an average of 283,587,831 clean RNA reads per sample and 18,528 testis-expressed genes (TPM>0.2 in 75% of samples). In total, 2,178 genes had significant cis-eQTL at a false discovery rate of 5% (11.76% of expressed genes). Several genes associated with fertility, including SPATA4 and SPATA22 (which are responsible for reproductive processes), had significant cis-eQTL and variation in transcript abundance across genotypes.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wageningen Academic Publishers
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
eQTL mapping in Brown Swiss bulls to identify variants associated with male fertility
en_US
dc.type
Other Conference Item
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2023-02-09
ethz.book.title
Proceedings of the 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
en_US
ethz.journal.issue
2273
en_US
ethz.pages.start
2276
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.event
12th World Congress on Genetics Applied to Livestock Production (WCGALP 2022)
en_US
ethz.event.location
Rotterdam, Netherlands
en_US
ethz.event.date
July 3-8, 2022
en_US
ethz.publication.place
Wageningen
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02703 - Institut für Agrarwissenschaften / Institute of Agricultural Sciences::09575 - Pausch, Hubert / Pausch, Hubert
en_US
ethz.date.deposited
2023-09-26T08:06:42Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-09-26T08:10:13Z
ethz.rosetta.lastUpdated
2024-02-03T05:21:44Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=eQTL%20mapping%20in%20Brown%20Swiss%20bulls%20to%20identify%20variants%20associated%20with%20male%20fertility&rft.date=2022&rft.issue=2273&rft.spage=2276&rft.au=Mapel,%20Xena%20Marie&Hiltpold,%20Maya&Lloret%20i%20Villas,%20Audald&Pausch,%20Hubert&rft.isbn=978-90-8686-940-4&rft.genre=unknown&rft_id=info:doi/10.3920/978-90-8686-940-4_548&rft.btitle=Proceedings%20of%20the%2012th%20World%20Congress%20on%20Genetics%20Applied%20to%20Livestock%20Production%20(WCGALP)
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