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dc.contributor.author
Silander, Olin K.
dc.contributor.author
Tenaillon, Olivier
dc.contributor.author
Chao, Lin
dc.date.accessioned
2019-06-05T16:37:57Z
dc.date.available
2017-06-08T17:21:31Z
dc.date.available
2019-06-05T16:37:57Z
dc.date.issued
2007-04-03
dc.identifier.issn
1544-9173
dc.identifier.issn
1545-7885
dc.identifier.other
10.1371/journal.pbio.0050094
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/6376
dc.identifier.doi
10.3929/ethz-b-000006376
dc.description.abstract
The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a plateau. Using experimental evolution with bacteriophage, we show here that the converse is also true. In populations small enough such that drift overwhelms selection and causes fitness to decrease, fitness declines down to a plateau. We demonstrate theoretically that both of these phenomena must be due either to changes in the ratio of beneficial to deleterious mutations, the size of mutational effects, or both. We use mutation accumulation experiments and molecular data from experimental evolution to show that the most significant change in mutational effects is a drastic increase in the rate of beneficial mutation as fitness decreases. In contrast, the size of mutational effects changes little even as organismal fitness changes over several orders of magnitude. These findings have significant implications for the dynamics of adaptation.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS Biology
ethz.journal.volume
5
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
PLoS biol.
ethz.pages.start
e94 / 922
en_US
ethz.pages.end
931
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
004606893
ethz.publication.place
Lawrence, KS
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.date.deposited
2017-06-08T17:21:38Z
ethz.source
ECIT
ethz.identifier.importid
imp59364ba01854950443
ethz.ecitpid
pub:16776
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-24T10:02:01Z
ethz.rosetta.lastUpdated
2019-06-05T16:38:06Z
ethz.rosetta.versionExported
true
ethz.COinS
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