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dc.contributor.author
Vela-Gallego, Sonia
dc.contributor.author
Lewandowski, Bartosz
dc.contributor.author
Möhler, Jasper Samuel
dc.contributor.author
Puente, Alonso
dc.contributor.author
Gil-Cantero, David
dc.contributor.author
Wennemers, Helma
dc.contributor.author
de la Escosura, Andrés
dc.date.accessioned
2024-02-26T12:43:00Z
dc.date.available
2023-11-26T06:55:37Z
dc.date.available
2023-11-27T11:48:10Z
dc.date.available
2024-02-26T12:43:00Z
dc.date.issued
2024-01-02
dc.identifier.issn
0947-6539
dc.identifier.issn
1521-3765
dc.identifier.other
10.1002/chem.202303395
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/643701
dc.identifier.doi
10.3929/ethz-b-000643701
dc.description.abstract
Biohybrid catalysts that operate in aqueous media are intriguing for systems chemistry. In this paper, we investigate whether control over the self-assembly of biohybrid catalysts can tune their properties. As a model, we use the catalytic activity of functional hybrid molecules consisting of a catalytic H-DPro-Pro-Glu tripeptide, derivatized with fatty acid and nucleobase moieties. This combination of simple biological components merged the catalytic properties of the peptide with the self-assembly of the lipid, and the structural ordering of the nucleobases. The biomolecule hybrids self-assemble in aqueous media into fibrillar assemblies and catalyze the reaction between butanal and nitrostyrene. The interactions between the nucleobases enhanced the order of the supramolecular structures and affected their catalytic activity and stereoselectivity. The results point to the significant control and ordering that nucleobases can provide in the self-assembly of biologically inspired supramolecular catalysts.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-VCH
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
assemblies
en_US
dc.subject
catalysis
en_US
dc.subject
lipopeptides
en_US
dc.subject
nucleobases
en_US
dc.subject
supramolecular
en_US
dc.title
Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2023-10-25
ethz.journal.title
Chemistry - A European Journal
ethz.journal.volume
30
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Chem. Eur. J.
ethz.pages.start
e202303395
en_US
ethz.size
6 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03940 - Wennemers, Helma / Wennemers, Helma
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03940 - Wennemers, Helma / Wennemers, Helma
ethz.date.deposited
2023-11-26T06:55:43Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2024-02-26T12:43:01Z
ethz.rosetta.lastUpdated
2024-02-26T12:43:01Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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