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dc.contributor.author
Bebié, Pascal
dc.contributor.author
Lustermann, Werner
dc.contributor.author
Debus, Jan
dc.contributor.author
Ritzer, Christian
dc.contributor.author
Dissertori, Günther
dc.contributor.author
Weber, Bruno
dc.date.accessioned
2023-12-18T10:31:10Z
dc.date.available
2023-12-18T08:29:56Z
dc.date.available
2023-12-18T10:31:10Z
dc.date.issued
2023-12-12
dc.identifier.other
10.1186/s40658-023-00603-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/648120
dc.identifier.doi
10.3929/ethz-b-000648120
dc.description.abstract
Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a novel Positron Emission Tomography insert for a 7T Bruker BioSpec 70/30 Ultra Shield Refrigerated Magnetic Resonance Imaging (MRI) system. It facilitates truly simultaneous quantitative imaging in mice and rats at injected activities as high as 500MBq . Exploitation of the resulting high count rates enables quick image formation at few seconds per frame. In this investigation, key performance parameters of SAFIR-I have been determined according to the evaluations outlined in the National Electrical Manufacturers Association (NEMA) Standards Publication NU 4-2008 (NEMA-NU4) protocol. Results: Using an energy window of 391 to 601keV and a Coincidence Timing Window of 500ps , the following performance was observed: The average spatial resolution at 5mm radial offset (Full Width at Half Maximum) is 2.54mm when using Filtered Backprojection, 3D Reprojection reconstruction. For the mouse- and rat-like phantoms, the maximal Noise-Equivalent Count Rates (NECRs) are 1368kcps at the highest tested average effective concentration of 14.7MBqcc-1 , and 713kcps at the highest tested average effective concentration of 1.72MBqcc-1 , respectively. The NECR peak is not yet reached for either of these cases. The peak sensitivity is 1.46% . The Image Quality phantom uniformity standard deviation is 4.8% . The Recovery Coefficient for the 5mm rod is (1.08 ± 0.10) . The Spill-Over Ratios are (0.22 ± 0.03) and (0.22 ± 0.02) , for the water- and air-filled cylinder, respectively. An accuracy of 4.3% was achieved for the quantitative calibration of reconstructed voxel values. Conclusions: The measured performance parameters indicate that the various design goals have been achieved. SAFIR-I offers excellent performance, especially at the high activities it was designed for. This facilitates planned experiments with fast tracer kinetics in small animals. Ways to potentially improve performance can still be explored. Simultaneously, further performance gains can be expected for a forthcoming insert featuring 2.7 times longer axial coverage named Small Animal Fast Insert for MRI detector II (SAFIR-II).
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Positron Emission Tomography
en_US
dc.subject
PET/MRI
en_US
dc.subject
Preclinical imaging
en_US
dc.subject
SAFIR
en_US
dc.subject
NEMA NU 4-2008
en_US
dc.subject
Performance characterization
en_US
dc.title
SAFIR-I: first NEMA NU 4-2008-based performance characterization
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
EJNMMI Physics
ethz.journal.volume
10
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
81
en_US
ethz.size
20 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02010 - Dep. Physik / Dep. of Physics::02532 - Institut für Teilchen- und Astrophysik / Inst. Particle Physics and Astrophysics::03593 - Dissertori, Günther / Dissertori, Günther
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02010 - Dep. Physik / Dep. of Physics::02532 - Institut für Teilchen- und Astrophysik / Inst. Particle Physics and Astrophysics::03593 - Dissertori, Günther / Dissertori, Günther
ethz.date.deposited
2023-12-18T08:29:57Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2023-12-18T10:31:11Z
ethz.rosetta.lastUpdated
2024-02-03T08:05:16Z
ethz.rosetta.versionExported
true
ethz.COinS
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