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dc.contributor.author
Bozuyuk, Ugur
dc.contributor.author
Yildiz, Erdost
dc.contributor.author
Han, Mertcan
dc.contributor.author
Demir, Sinan Ozgun
dc.contributor.author
Sitti, Metin
dc.date.accessioned
2024-02-05T13:10:21Z
dc.date.available
2024-02-05T13:10:21Z
dc.date.issued
2023-11-22
dc.identifier.issn
1613-6810
dc.identifier.issn
1613-6829
dc.identifier.other
10.1002/smll.202303396
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/657751
dc.identifier.doi
10.3929/ethz-b-000625101
dc.description.abstract
Controlled microrobotic navigation inside the body possesses significant potential for various biomedical engineering applications. Successful application requires considering imaging, control, and biocompatibility. Interaction with biological environments is also a crucial factor in ensuring safe application, but can also pose counterintuitive hydrodynamic barriers, limiting the use of microrobots. Surface rolling microrobots or surface microrollers is a robust microrobotic platform with significant potential for various applications; however, conventional spherical microrollers have limited locomotion ability over biological surfaces due to microtopography effects resulting from cell microtopography in the size range of 2–5 µm. Here, the impact of the microtopography effect on spherical microrollers of different sizes (5, 10, 25, and 50 µm) is investigated using computational fluid dynamics simulations and experiments. Simulations revealed that the microtopography effect becomes insignificant for increasing microroller sizes, such as 50 µm. Moreover, it is demonstrated that 50 µm microrollers exhibited smooth locomotion ability on in vitro cell layers and inside blood vessels of a chicken embryo model. These findings offer rational design principles for surface microrollers for their potential practical biomedical applications.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-VCH
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
computational fluid dynamics
en_US
dc.subject
hydrodynamics
en_US
dc.subject
lab-on-a-chip
en_US
dc.subject
medical microrobots
en_US
dc.subject
microrobotics
en_US
dc.subject
surface microrollers
en_US
dc.title
Size-Dependent Locomotion Ability of Surface Microrollers on Physiologically Relevant Microtopographical Surfaces
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2023-07-24
ethz.journal.title
Small
ethz.journal.volume
19
en_US
ethz.journal.issue
47
en_US
ethz.pages.start
2303396
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::09726 - Sitti, Metin (ehemalig) / Sitti, Metin (former)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::09726 - Sitti, Metin (ehemalig) / Sitti, Metin (former)
ethz.date.deposited
2023-08-03T06:35:01Z
ethz.source
WOS
ethz.source
BATCH
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2024-02-05T13:10:23Z
ethz.rosetta.lastUpdated
2024-02-05T13:10:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/625101
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/657343
ethz.COinS
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