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dc.contributor.author
Bodenmiller, Bernd
dc.contributor.author
Malmstrom, Johan
dc.contributor.author
Gerrits, Bertran
dc.contributor.author
Campbell, David
dc.contributor.author
Lam, Henry
dc.contributor.author
Schmidt, Alexander
dc.contributor.author
Rinner, Oliver
dc.contributor.author
Mueller, Lukas N.
dc.contributor.author
Shannon, Paul T.
dc.contributor.author
Pedrioli, Patrick G.
dc.contributor.author
Panse, Christian
dc.contributor.author
Lee, Hoo-Keun
dc.contributor.author
Schlapbach, Ralph
dc.contributor.author
Aebersold, Ruedi
dc.date.accessioned
2018-06-07T16:29:28Z
dc.date.available
2017-06-10T16:02:54Z
dc.date.available
2018-06-07T16:29:28Z
dc.date.issued
2007-01
dc.identifier.other
10.1038/msb4100182
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/65835
dc.identifier.doi
10.3929/ethz-b-000065835
dc.description.abstract
The ability to analyze and understand the mechanisms by which cells process information is a key question of systems biology research. Such mechanisms critically depend on reversible phosphorylation of cellular proteins, a process that is catalyzed by protein kinases and phosphatases. Here, we present PhosphoPep, a database containing more than 10 000 unique high‐confidence phosphorylation sites mapping to nearly 3500 gene models and 4600 distinct phosphoproteins of the Drosophila melanogaster Kc167 cell line. This constitutes the most comprehensive phosphorylation map of any single source to date. To enhance the utility of PhosphoPep, we also provide an array of software tools that allow users to browse through phosphorylation sites on single proteins or pathways, to easily integrate the data with other, external data types such as protein–protein interactions and to search the database via spectral matching. Finally, all data can be readily exported, for example, for targeted proteomics approaches and the data thus generated can be again validated using PhosphoPep, supporting iterative cycles of experimentation and analysis that are typical for systems biology research.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publ. Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject
Data integration
en_US
dc.subject
Drosophila
en_US
dc.subject
Interactive database
en_US
dc.subject
Phosphoproteomics
en_US
dc.subject
Systems biology
en_US
dc.title
PhosphoPep—a phosphoproteome resource for systems biology research in Drosophila Kc167 cells
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2007-10-16
ethz.journal.title
Molecular Systems Biology
ethz.journal.volume
3
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
139
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
004931271
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::08828 - Schlapbach, Ralph (Tit.-Prof.)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung / Domain VP Research::02207 - Functional Genomics Center Zurich / Functional Genomics Center Zurich
ethz.date.deposited
2017-06-10T16:04:26Z
ethz.source
ECIT
ethz.identifier.importid
imp593650839fa7044305
ethz.ecitpid
pub:104886
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T16:34:05Z
ethz.rosetta.lastUpdated
2020-02-15T13:28:18Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=PhosphoPep%E2%80%94a%20phosphoproteome%20resource%20for%20systems%20biology%20research%20in%20Drosophila%20Kc167%20cells&rft.jtitle=Molecular%20Systems%20Biology&rft.date=2007-01&rft.volume=3&rft.issue=1&rft.spage=139&rft.au=Bodenmiller,%20Bernd&Malmstrom,%20Johan&Gerrits,%20Bertran&Campbell,%20David&Lam,%20Henry&rft.genre=article&
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