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dc.contributor.author
Franz, Mathias
dc.contributor.author
Regoes, Roland R.
dc.contributor.author
Rolff, Jens
dc.date.accessioned
2024-04-02T13:32:23Z
dc.date.available
2024-03-26T07:20:38Z
dc.date.available
2024-04-02T13:32:23Z
dc.date.issued
2024-05-06
dc.identifier.issn
1471-2970
dc.identifier.issn
0962-8436
dc.identifier.other
10.1098/rstb.2023.0067
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/666216
dc.description.abstract
Host-pathogen interactions can be influenced by the host microbiota, as the microbiota can facilitate or prevent pathogen infections. In addition, members of the microbiota can become virulent. Such pathobionts can cause co-infections when a pathogen infection alters the host immune system and triggers dysbiosis. Here we performed a theoretical investigation of how pathobiont co-infections affect the evolution of pathogen virulence. We explored the possibility that the likelihood of pathobiont co-infection depends on the evolving virulence of the pathogen. We found that, in contrast to the expectation from classical theory, increased virulence is not always selected for. For an increasing likelihood of co-infection with increasing pathogen virulence, we found scenario-specific selection for either increased or decreased virulence. Evolutionary changes, however, in pathogen virulence do not always translate into similar changes in combined virulence of the pathogen and the pathobiont. Only in one of the scenarios where pathobiont co-infection is triggered above a specific virulence level we found a reduction in combined virulence. This was not the case when the probability of pathobiont co-infection linearly increased with pathogen virulence. Taken together, our study draws attention to the possibility that host-microbiota interactions can be both the driver and the target of pathogen evolution. This article is part of the theme issue 'Sculpting the microbiome: how host factors determine and respond to microbial colonization'.
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society
en_US
dc.subject
virulence evolution
en_US
dc.subject
pathogen
en_US
dc.subject
microbiota
en_US
dc.subject
dysbiosis
en_US
dc.subject
pathobiont
en_US
dc.subject
mathematical model
en_US
dc.title
How infection-triggered pathobionts influence virulence evolution
en_US
dc.type
Journal Article
dc.date.published
2024-03-18
ethz.journal.title
Philosophical Transactions of the Royal Society B: Biological Sciences
ethz.journal.volume
379
en_US
ethz.journal.issue
1901
en_US
ethz.journal.abbreviated
Phil. Trans. R. Soc. B
ethz.pages.start
20230067
en_US
ethz.size
9 p.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.status
published
en_US
ethz.date.deposited
2024-03-26T07:20:39Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2024-04-02T13:32:24Z
ethz.rosetta.lastUpdated
2024-04-02T13:32:24Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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