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dc.contributor.author
Pais, Michael-Alexander
dc.contributor.author
Papanikolaou, Athanasios
dc.contributor.author
Hoyos, Isabel Arenas
dc.contributor.author
Nissler, Robert
dc.contributor.author
De Brot, Simone
dc.contributor.author
Gogos, Alexander
dc.contributor.author
Rieben, Robert
dc.contributor.author
Constantinescu, Mihai A.
dc.contributor.author
Matter, Martin T.
dc.contributor.author
Herrmann, Inge
dc.contributor.author
Lese, Ioana
dc.date.accessioned
2024-04-15T09:53:48Z
dc.date.available
2024-04-02T08:29:51Z
dc.date.available
2024-04-15T09:53:48Z
dc.date.issued
2024
dc.identifier.issn
2296-4185
dc.identifier.other
10.3389/fbioe.2024.1363126
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/667034
dc.identifier.doi
10.3929/ethz-b-000667034
dc.description.abstract
Background: Seroma formation is a common postoperative complication. Fibrin-based glues are typically employed in an attempt to seal the cavity. Recently, the first nanoparticle (NP)-based treatment approaches have emerged. Nanoparticle dispersions can be used as tissue glues, capitalizing on a phenomenon known as 'nanobridging'. In this process, macromolecules such as proteins physically adsorb onto the NP surface, leading to macroscopic adhesion. Although significant early seroma reduction has been shown, little is known about long-term efficacy of NPs. The aim of this study was to assess the long-term effects of NPs in reducing seroma formation, and to understand their underlying mechanism.Methods: Seroma was surgically induced bilaterally in 20 Lewis rats. On postoperative day (POD) 7, seromas were aspirated on both sides. In 10 rats, one side was treated with NPs, while the contralateral side received only NP carrier solution. In the other 10 rats, one side was treated with fibrin glue, while the other was left untreated. Seroma fluid, blood and tissue samples were obtained at defined time points. Biochemical, histopathological and immunohistochemical assessments were made.Results: NP-treated sides showed no macroscopically visible seroma formation after application on POD 7, in stark contrast to the fibrin-treated sides, where 60% of the rats had seromas on POD 14, and 50% on POD 21. At the endpoint (POD 42), sides treated with nanoparticles (NPs) exhibited significant macroscopic differences compared to other groups, including the absence of a cavity, and increased fibrous adhesions. Histologically, there were more macrophage groupings and collagen type 1 (COL1) deposits in the superficial capsule on NP-treated sides.Conclusion: NPs not only significantly reduced early manifestations of seroma and demonstrated an anti-inflammatory response, but they also led to increased adhesion formation over the long term, suggesting a decreased risk of seroma recurrence. These findings highlight both the adhesive properties of NPs and their potential for clinical therapy.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Media
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
seroma formation
en_US
dc.subject
bioglass/ceria nanoparticle hybrids
en_US
dc.subject
animal rat model
en_US
dc.subject
anti-inflammatory response of nanoparticles
en_US
dc.subject
adhesive properties of nanoparticles
en_US
dc.title
Bioglass/ceria nanoparticle hybrids for the treatment of seroma: a comparative long-term study in rats
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2024-03-12
ethz.journal.title
Frontiers in Bioengineering and Biotechnology
ethz.journal.volume
12
en_US
ethz.journal.abbreviated
Front. Bioeng. Biotechnol.
ethz.pages.start
1363126
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Cutting-edge nanotechnology for seroma management
en_US
ethz.grant
Integrative Engineering of Metal Oxide Nanohybrid-based Surgical Adhesives: From Particle Design to Performance Assessment by Multiscale Analytics
en_US
ethz.identifier.wos
ethz.publication.status
published
en_US
ethz.grant.agreementno
207093
ethz.grant.agreementno
181290
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Bridge - Proof of Concept
ethz.grant.program
Eccellenza
ethz.date.deposited
2024-04-02T08:29:59Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2024-04-15T09:53:49Z
ethz.rosetta.lastUpdated
2024-04-15T09:53:49Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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