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dc.contributor.author
Pereira, Denise G.
dc.contributor.author
Antunes, Lusânia M.G.
dc.contributor.author
Graf, Ulrich
dc.contributor.author
Spanó, Mário A.
dc.date.accessioned
2019-10-16T12:28:04Z
dc.date.available
2017-06-10T19:00:41Z
dc.date.available
2019-10-16T12:25:23Z
dc.date.available
2019-10-16T12:28:04Z
dc.date.issued
2008
dc.identifier.issn
1415-4757
dc.identifier.issn
1678-4685
dc.identifier.other
10.1590/S1415-47572008000500024
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/69185
dc.identifier.doi
10.3929/ethz-b-000069185
dc.description.abstract
Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in marker-heterozygous flies resulted mainly from mitotic recombination. At low concentrations, P. ginseng had antirecombinogenic activity that was independent of the concentration of extract used. Recombination events may promote cancer, but little is known about the ability of P. ginseng to inhibit such recombination or modulate DNA repair mechanisms.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
SBG
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Antigenotoxicity
en_US
dc.subject
SMART
en_US
dc.subject
Wing spot test
en_US
dc.title
Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
ethz.journal.title
Genetics and Molecular Biology
ethz.journal.volume
31
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Genet. Mol. Biol.
ethz.pages.start
947
en_US
ethz.pages.end
955
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
001979632
ethz.publication.place
Ribeirão Preto
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-10T19:04:35Z
ethz.source
ECIT
ethz.identifier.importid
imp593650c6f1b5853466
ethz.ecitpid
pub:109711
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T16:50:27Z
ethz.rosetta.lastUpdated
2019-10-16T12:28:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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