Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.
Open access
Date
2024-09-03Type
- Dataset
ETH Bibliography
yes
Altmetrics
Permanent link
https://doi.org/10.3929/ethz-b-000692053Contributors
Contact person: Snijder, Berend
Data collector: Wegmann, Rebekka
Project leader: Snijder, Berend
Publisher
ETH ZurichOrganisational unit
02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology
Notes
scRNA dataset: TuPro_AML_scRNA_counts_all_samples_SCE.RDS
R Dataset (SingleCellExperiment) generated with R 4.1.3 and SingleCellExperiment version 1.14.1.
The dataset contains the following slots:
* assays:
counts: raw counts
* colData: Cell-level metadata
barcodes: The cell arcode
fractionMT: Fraction mitochondrail genes per cell
n_umi: Total number of UMIs per cell
n_gene: Total number of genes per cell
log_umi: log10 total number of UMIs per cell
g2m_score: Cell cycle phase score for G2M
s_score: Cell cycle phase score for S
cycle_phase: predicted cell cycle phase
celltype_major_full_ct_name: Major cell typ efull name
celltype_major: Major cell type hort name
celltype_final_full_ct_name: Cell subtype full name
celltype_final: Cell subtype short name
sample_id
* rowData: Gene-level metadata
gene_ids
gene_names
CyTOF dataset: TuPro_AML_CyTOF_singlecell_data_SCE
R Dataset (SingleCellExperiment) generated with R 4.1.3 and SingleCellExperiment version 1.14.1.
* Assays:
counts:
exprs:
scaled: Scaled normalized intensity. This is what was used to generate all Figures in the publication.
counts_raw:
exprs_raw:
* colData: Cell-level metadata
file_name, bc_id, sample, group, run: CyTOF run metadata
type: Sample type (blood or bone marrow)
sample_id: TuPro sample ID
pred_id: Predicted cell type [char]
pred_n: Predicted cell type [integer]
* rowData: Marker-level metadata
channel_name: Name of the metal ion correspondng to this marker.
marker_name: Protein name
marker_class: Type of marker (state v.s. other)
use_channel: Logical - use this channel for analysis? Used to exclude barcoding and live/dead channels.
channel_group, channel_group_integer: Biological processes the channel identifies, e.g. specific cell type, signalling, cell death
tsne_channel:
channel_order:
channel_group_order:
common_channel:
T_channel:
M_channel:
cluster_channel: Logical - use this channel for clustering?
bead_channel: Logical - is this channel used to measure beads?
is_bc: Logical - is this a barcode channel?More
Show all metadata
ETH Bibliography
yes
Altmetrics