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dc.contributor.author
Dodgson, James
dc.contributor.author
Chessel, Anatole
dc.contributor.author
Yamamoto, Miki
dc.contributor.author
Vaggi, Federico
dc.contributor.author
Cox, Susan
dc.contributor.author
Rosten, Edward
dc.contributor.author
Albrecht, David
dc.contributor.author
Geymonat, Marco
dc.contributor.author
Csikasz-Nagy, Attila
dc.contributor.author
Sato, Masamitsu
dc.contributor.author
Carazo-Salas, Rafael E.
dc.date.accessioned
2018-09-05T11:04:11Z
dc.date.available
2017-06-10T19:13:40Z
dc.date.available
2018-09-05T11:04:11Z
dc.date.issued
2013
dc.identifier.other
10.1038/ncomms2813
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/69445
dc.identifier.doi
10.3929/ethz-b-000069445
dc.description.abstract
Cell polarity is regulated by evolutionarily conserved polarity factors whose precise higher-order organization at the cell cortex is largely unknown. Here we image frontally the cortex of live fission yeast cells using time-lapse and super-resolution microscopy. Interestingly, we find that polarity factors are organized in discrete cortical clusters resolvable to ~50–100 nm in size, which can form and become cortically enriched by oligomerization. We show that forced co-localization of the polarity factors Tea1 and Tea3 results in polarity defects, suggesting that the maintenance of both factors in distinct clusters is required for polarity. However, during mitosis, their co-localization increases, and Tea3 helps to retain the cortical localization of the Tea1 growth landmark in preparation for growth reactivation following mitosis. Thus, regulated spatial segregation of polarity factor clusters provides a means to spatio-temporally control cell polarity at the cell cortex. We observe similar clusters in Saccharomyces cerevisiae and Caenorhabditis elegans cells, indicating this could be a universal regulatory feature.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.title
Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
dc.date.published
2013-05-14
ethz.journal.title
Nature Communications
ethz.journal.volume
4
en_US
ethz.pages.start
1834
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-10T19:14:52Z
ethz.source
ECIT
ethz.identifier.importid
imp593650cc34c9f73292
ethz.ecitpid
pub:110090
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-25T18:46:36Z
ethz.rosetta.lastUpdated
2019-02-03T05:23:56Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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