Synthetically defined glycoprotein vaccines: current status and future directions
Bernardes, Gonçalo J.L.
- Journal Article
Rights / licenseCreative Commons Attribution 3.0 Unported
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines. Show more
Journal / seriesChemical Science
Pages / Article No.
PublisherRoyal Society of Chemistry
MoreShow all metadata