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dc.contributor.author
Delmonte, Sonja
dc.contributor.author
Gallagher, Louise
dc.contributor.author
O'Hanlon, Erik
dc.contributor.author
McGrath, Jane
dc.contributor.author
Balsters, Joshua H.
dc.date.accessioned
2018-08-30T12:11:11Z
dc.date.available
2017-06-10T20:12:45Z
dc.date.available
2018-08-30T12:11:11Z
dc.date.issued
2013-08
dc.identifier.issn
1662-5161
dc.identifier.other
10.3389/fnhum.2013.00430
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/70634
dc.identifier.doi
10.3929/ethz-b-000070634
dc.description.abstract
Abnormalities in frontostriatal circuitry potentially underlie the two core deficits in Autism Spectrum Disorder (ASD); social interaction and communication difficulties and restricted interests and repetitive behaviors. Whilst a few studies have examined connectivity within this circuitry in ASD, no previous study has examined both functional and structural connectivity within the same population. The present study provides the first exploration of both functional and structural frontostriatal connectivity in ASD. Twenty-eight right-handed Caucasian male ASD (17.28 ± 3.57 years) and 27 right-handed male, age and IQ matched controls (17.15 ± 3.64 years) took part in the study. Resting state functional connectivity was carried out on 21 ASD and control participants, and tractography was carried out on 22 ASD and 24 control participants, after excluding subjects for excessive motion and poor data quality. Functional connectivity analysis was carried out between the frontal cortex and striatum after which tractography was performed between regions that showed significant group differences in functional connectivity. The ASD group showed increased functional connectivity between regions in the frontal cortex [anterior cingulate cortex (ACC), middle frontal gyrus (MFG), paracingulate gyrus (Pcg) and orbitofrontal cortex (OFC)], and striatum [nucleus accumbens (NAcc) and caudate]. Increased functional connectivity between ACC and caudate was associated with deactivation to social rewards in the caudate, as previously reported in the same participants. Greater connectivity between the right MFG and caudate was associated with higher restricted interests and repetitive behaviors and connectivity between the bilateral Pcg and NAcc, and the right OFC and NAcc, was negatively associated with social and communicative deficits. Although tracts were reliably constructed for each subject, there were no group differences in structural connectivity. Results are in keeping with previously reported increased corticostriatal functional connectivity in ASD.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
Autism Spectrum Disorder
en_US
dc.subject
Connectivity
en_US
dc.subject
Frontostriatal
en_US
dc.subject
Striatum
en_US
dc.subject
fMRI
en_US
dc.subject
DTI
en_US
dc.subject
Social reward
en_US
dc.title
Functional and structural connectivity of frontostriatal circuitry in Autism Spectrum Disorder
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2013-08-06
ethz.journal.title
Frontiers in human neuroscience
ethz.journal.volume
7
en_US
ethz.journal.abbreviated
Front. hum. neurosci.
ethz.pages.start
430
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.date.deposited
2017-06-10T20:12:59Z
ethz.source
ECIT
ethz.identifier.importid
imp593650e4e534012364
ethz.ecitpid
pub:111915
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T10:18:32Z
ethz.rosetta.lastUpdated
2018-11-08T01:17:48Z
ethz.rosetta.versionExported
true
ethz.COinS
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